刘勇

发布者:王晨浏览次数:11

姓名:刘勇

职称:研究员

邮箱:y.liu@nankai.edu.cn

办公地址:南开大学津南校区综合实验楼C511

课题组网页http://www.liu-lab-biomat.com/

研究方向:

1、智能响应型高分子聚合物的设计、合成与表征;纳米组装体制备、分离、多功能化;

2、用于克服细菌及癌症耐药性的智能高分子聚合物纳米体系;

3、天然生物材料及其在细菌感染和癌症免疫治疗中的应用。


教育背景与工作经历:

20069-20106月,四川大学,学士(导师:王玉忠 院士);

20106-20136月,南开大学,硕士(导师:王忠文 教授);

20136-20166月,南开大学,博士(导师:史林启 教授);

20166-20196月,荷兰格罗宁根大学医学中心,博士(导师:Henk Busscher教授);

20197-20214月,苏州大学,功能纳米与软物质研究院,副研究员;

20215-20245月,国科温州研究院(温州生物材料与工程研究所),研究员/课题组长;

20246-至今,南开大学药物化学生物学全国重点实验室,研究员/博导。

研究成果:

国家自然科学基金优秀青年基金、浙江省杰出青年基金获得者。研究领域为具有生物活性的分子材料设计、合成及自组装,研究其在克服细菌耐药方面的应用。近年来,以第一作者或通讯作者在Chem. Soc. Rev., Adv. Mater., Nat. Commun., Adv. Funct. Mater., ACS Nano, Adv. Sci.等杂志上发表论文80余篇,其中影响因子大于15的文章22篇。申请发明专利30余项,其中10项获得授权。

代表性论文:

1. Xinghong Zhao#,*, Xinyi Zhong#, Shinong Yang#, Jiarong Deng, Kai Deng, Zhengqun Huang, Yuanfeng Li, Zhongqiong Yin, Yong Liu*, Jakob H. Vield, Hongping Wan*. Guiding antibiotics towards their target using bacteriophage proteins. Nature Communications, 2024, 15, 5287.

2. Yuanfeng Li#, Lei Hua#, Wei He#, Lei Chen, Yin-Zi Piao, Mengna Peng, Dongdong Li*, Linqi Shi, Yong Liu*. Microenvironment-Adaptive Metallo-Polymeric Nanodecoys via Subcomponent Coordination for Bacterial Biofilm Eradication and Immunomodulation. Adv. Funct. Mater., 2024, 2405487.

3. Lei Chen#, Mengna Peng#, Huaping Li#, Jianan Zhou, Wei He, Rongdang Hu,* Fangfu Ye,* Yuanfeng Li,* Linqi Shi, and Yong Liu*. Metal-Phenolic Network with Pd Nanoparticle Nodes Synergizes Oxidase-Like and Photothermal Properties to Eradicate Oral Polymicrobial Biofilm-Associated Infections. Adv. Mater. 2024, 36, 2306376.

4. Xiaowen Hu#, Dongdong Li#, Huaping Li#, Yinzi Piao*, Hongping Wan, Tieli Zhou, Mahdi Karimi, Xinghong Zhao,* Yuanfeng Li,* Linqi Shi, Yong Liu*. Reaction-Induced Self-Assembly of Polymyxin Mitigates Cytotoxicity and Reverses Drug Resistance, Adv. Mater., 2024, 2406156.

5. Yaran Wang, Fan Wu, Yuanfeng Li*, Siran Wang, Yijin Ren, Linqi Shi,* Henny C. van der Mei*, Yong Liu*. Ellagic Acid-Modified Gold Nanoparticles to Combat Multi-Drug Resistant Bacterial Infections In Vitro and In Vivo. Materials Horizons, 2024, https://doi.org/10.1039/D4MH00642A

6. Lei Chen#, Mengna Peng#, Wei He#, Yuanfeng Li*, Xiaoli Hu*, Jian Xiao*, Linqi Shi, Yong Liu*. Microenvironment-Adaptive Nanodecoy Synergizes Bacterial Eradication, Inflammation Alleviation, and Immunomodulation in Promoting Biofilm-Associated Diabetic Chronic Wound Healing Cascade. Aggregate, 2024, e640.

7. Yin-Zi Piao#, Linzhu Su#, Xiaoli Hu#, Wei He, Xiaowen Hu, Calvin Andeve Omolo, Thirumala Govender,*, Huaping Li,*, Haodan Xue, Yicen Ge, Yong Liu* , Linqi Shi, Yuanfeng Li*. One-component lipidic bicontinuous nanospheres as a smart drug loading platform to eradicate candida biofilms in oral and vaginal infection. Nano Today, 2024, 102123.

8. Yumeng Wang#, Xinghong Zhao#, Xingjian Zhou#, Juqin Dai, Xiaowen Hu, Yinzi Piao, Guangyue Zu, Jian Xiao*, Keqing Shi*, Yong Liu*, Yuanfeng Li*, Linqi Shi. A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing. Journal of Controlled Release, 2024, 368, 740-755.

9. Xiaowen Hu#, Yuanfeng Li#, Yinzi Piao#, Mahdi Karimi, Yang Wang*, Feng Wen, Huaqiong Li, Linqi Shi*, and Yong Liu*. Two-Tailed Dynamic Covalent Amphiphile Combats Bacterial Biofilms. Adv. Mater. 2023, 35, 2301623.

10. Lei Chen,# Mengna Peng,# Jianan Zhou, Xiaowen Hu, Yinzi Piao, Huaping Li,* Rongdang Hu,* Yuanfeng Li,* Linqi Shi, and Yong Liu*. Supramolecular Photothermal Cascade Nano-Reactor Enables Photothermal Effect, Cascade Reaction, and In Situ Hydrogelation for Biofilm-Associated Tooth-Extraction Wound Healing. Adv. Mater. 2023, 35, 2301664.

11. Yuxun Ding#, Xiaowen Hu#, Yinzi Piao, Rong Huang, Xiaojian Yan*, Hui Sun, Yuanfeng Li*, Linqi Shi, Yong Liu*. Lipid Prodrug Nano-Assemblies via Dynamic Covalent Boronates. ACS Nano, 2023, 17, 6601–6614.

12. Yizhou Zhan#, Xiaowen Hu#, Yuanfeng Li*, Yaran Wang, Hua Chen, Calvin Omolo, Thirumala Govender, Huaping Li*, Fan Huang*, Linqi Shi, Xiaoli Hu*, Yong Liu*. Antimicrobial Hybrid Amphiphile via Dynamic Covalent Bonds Enables Bacterial Biofilm Dispersal and Bacteria Eradication. Adv. Funct. Mater., 2023, 33, 2214299. 

13. Fan Wu#, Jinghang Ma#, Yang Wang,* Lingping Xie, Xiaojian Yan, Linqi Shi, Yuanfeng Li*, Yong Liu*. Single copper atom photocatalyst powers an integrated catalytic cascade for drug-resistant bacteria elimination. ACS Nano, 2023, 17, 2980-2991.

14. Yuanfeng Li#, Yin-Zi Piao#, Hua Chen#, Keqing Shi, Juqin Dai, Siran Wang, Tieli Zhou*, Anh-Tuan Le, Yaran Wang, Fan Wu, Rujiang Ma*, Linqi Shi, Yong Liu*. Dynamic covalent nano-networks comprising antibiotics and polyphenols orchestrate bacterial drug resistance reversal and inflammation alleviation. Bioact. Mater., 2023, 27, 288-302.

社会兼职:

2024年《Colloids and Surfaces B: Biointerfaces》杂志(IF:5.4)副主编

2023年《Research》《Journal of Materials Science Technology》青年编委

荣誉称号:

国家自然科学基金优秀青年基金、浙江省杰出青年基金获得者

2023年 中国化学会高分子青年学者奖 (5/年)

2022年 浙江省科学进步二等奖

2021年 温州市“瓯越海智计划”入选者

2020年 江苏省“双创博士”

2019年 国家优秀自费留学生奖学金 (全球每年500人)

2019年 荷兰van de Mond研究奖 (全荷兰每年十个名额)