姓名：董建桐
职称：研究员
办公地址：南开大学津南校区交叉大楼B座503
课题组网页：https://panglab.nankai.edu.cn/info/1023/1410.htm
研究方向：
1.基于微流控芯片的病原体、外泌体及类器官分析
2.基于核酸动态组装的仿生、传感与成像系统
3.基于智能纳米材料靶向递送的精准医学分析
教育背景与工作经历：
1. 2010--2014，山东大学，化学基地专业，理学学士
2. 2014--2021，北京大学，分析化学专业，理学博士
3. 2017--2019，美国加州大学洛杉矶分校，联合培养
4. 2021--2025，以色列耶路撒冷希伯来大学，博士后
5. 2025年至今，南开大学化学学院，研究员/博士生导师
研究成果：
1. 已在微流控分析、核酸动态传感和生物医学检测领域以第一/通讯作者在Nat.Chem., J.Am.Chem.Soc., Sci.Adv., Angew.Chem.Int.Ed., Nat.Commun., Adv.Mater., Chem.Soc.Rev., ACS Nano, Adv.Funct.Mater., Anal. Chem.等国际知名期刊接收/发表SCI论文20余篇。
2.代表性论文：
1. J. Dong, I. Willner*, Dynamic Transcription Frameworks, Nat. Chem., 2025, in press.
2. J. Dong, F. Xia*, F. Huang*, and I. Willner*, Dynamic Transcription Machineries in Protocells, J. Am. Chem. Soc., 2025, 147, 18359–18373.
3. J. Dong, I. Willner*, Photochemically Triggered, Transient, and Oscillatory Transcription Machineries Guide Temporal Modulation of Fibrinogenesis, J. Am. Chem. Soc., 2025, 147, 2216–2227.
4. J. Dong, I. Willner*, Transient Transcription Machineries Modulate Dynamic Functions of G-Quadruplexes: Temporal Regulation of Biocatalytic Circuits, Gene Replication and Transcription, Angew. Chem. Int. Ed., 2023, 62, e202307898.
5. J. Dong, Y. J. Jan, J. Cheng, R. Y. Zhang, M. Meng, M. Smalley, P.-J. Chen, X. Tang, P. Tseng, L. Bao, T.-Y. Huang, D. Zhou, Y. Liu, X. Chai, H. Zhang, A. Zhou, V. G. Agopian, E. M. Posadas, J.-J. Shyue, S. J. Jonas, P. S. Weiss, M. Li*, G. Zheng*, H.-h. Yu*, M. Zhao*, H.-R. Tseng*, and Y. Zhu*, Covalent Chemistry on Nanostructured Substrates Enables Noninvasive Quantification of Gene Rearrangements in Circulating Tumor Cells, Sci. Adv., 2019, 5, eaav9186.
6. J. Dong#, J.-F. Chen#, M. Smalley, M. Zhao, Z. Ke*, Y. Zhu*, and H.-R. Tseng*, Nanostructured Substrates for Detection and Characterization of Circulating Rare Cells: From Materials Research to Clinical Applications, Adv. Mater., 2020, 32, 1903663.
7. J. Dong, M. P. O’ Hagan, and I. Willner*, Switchable and Dynamic G-Quadruplexes and Their Applications, Chem. Soc. Rev., 2022, 51, 7631–7661.
8. J. Dong, I. Willner*, Dynamic Transcription Machineries Guide the Synthesis of Temporally Operating DNAzymes, Gated and Cascaded DNAzyme Catalysis, ACS Nano, 2023, 17, 687–696.
9. J. Dong, Y. Ouyang, J. Wang, M. P. O’ Hagan, and I. Willner*, Assembly of Dynamic Gated and Cascaded Transient DNAzyme Networks, ACS Nano, 2022, 16, 6153–6164.
10. J. Dong, R. Y. Zhang, N. Sun, J. Hu, M. D. Smalley, A. Zhou, Y. Hua, W. Rothermich, M. Chen, J. Chen, J. Ye, P.-C. Teng, D. Qi, J. A. Toretsky, J. S. Tomlinson, M. Li, P. S. Weiss, S. J. Jonas, N. Federman, L. Wu, M. Zhao*, H-.R. Tseng*, Y. Zhu*, Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies, Adv. Funct. Mater., 2020, 30, 2003237.
11. M. Ji, J. Dong*, Z. Ye, J. Kang, G. Han, X. Hong, Y, Wei, X, Chen*, W. Sun*, and D. Liu*, Endogenous HClO-Gated Cascade MicroRNA Imaging for Precise Diagnosis of Atherosclerosis In Vivo, J. Am. Chem. Soc., 2025, 147, 7113–7126. (*co-corresponding author)
12. X. Wang, J. Dong*, J. Kang, X. Chen, X. Hong, J. Chen, W. Du, H. Cai, and D. Liu*, Self-Adaptive Release of Stem Cell-Derived Exosomes from a Multifunctional Hydrogel for Accelerating MRSA-Infected Diabetic Wound Repair, J. Am. Chem. Soc., 2025, 147, 16362–16378. (*co-corresponding author)
13. H. Liu#, J. Dong#, Z. Duan, F. Xia*, I. Willner*, and F. Huang*, Light-Activated CRISPR-Cas12a for Amplified Imaging of MicroRNA in Cell Cycle Phases at Single-Cell Levels, Sci. Adv., 2024, 10, eadp6166. (#co-first author)
14. H. Liu#, J. Dong#, R. Wu#, J. Dai*, X. Lou, F. Xia, I. Willner*, and F. Huang*, Light-Triggered CRISPR/Cas12a for Genomic Editing and Tumor Regression, Angew. Chem. Int. Ed., 2025, e202502892. (#co-first author)
15. Y. Afshar#, J. Dong#, P. Zhao, L. Li, S. Wang, R. Y. Zhang, C. Zhang, O. Yin, C. S. Han, B. D. Einerson, T. L. Gonzalez, H. Zhang, A. Zhou, Z. Yang, S.-J. Chou, N. Sun, J. Cheng, H. Zhu, J. Wang, T. X. Zhang, Y.-T. Lee, J. J. Wang, P.-C. Teng, P. Yang, D. Qi, M. Zhao, M.-S. Sim, R. Zhe, J. D. Goldstein, J. Williams, X. Wang, Q. Zhang, L. D. Platt, C. Zou*, M. D. Pisarska*, H.-R. Tseng*, and Y. Zhu*, Circulating Trophoblast Cell Clusters for Early Detection of Placenta Accreta Spectrum Disorders, Nat. Commun., 2021, 12, 4408. (#co-first author)
社会兼职：
1. 《Journal of Analysis and Testing》青年编委
荣誉称号：
2021年北京大学优秀毕业生