姓名：杨云帆
职称：研究员
邮箱：yunfanyang@nankai.edu.cn
办公地址：天津市海河教育园区南开大学津南校区综合实验楼D222
研究方向：代谢感知，亚细胞结构，机体稳态
教育背景与工作经历：
2005年9月-2009年6月，南开大学，学士学位；
2009年9月-2014年6月，南开大学，博士学位；2015年1月-2020年6月，耶鲁大学（Yale University），PostdocAssociate/Fellow；
2020年7月-2020年12月，耶鲁大学（Yale University），Associate Research Scientist；
2020年12月-2025年12月，山东大学，教授；
研究成果：
机体稳态失衡是多种重大疾病的重要病理基础。本课题组聚焦环境感知与机体稳态调控，系统解析小分子代谢物、亚细胞信号感知结构及脂肪组织在代谢稳态维持中的功能与分子机制，重点揭示环境信号驱动下细胞与组织适应性响应的调控规律，深化对代谢稳态调控网络及相关疾病发生机制的系统性理解。
分条列出代表性论文
Luwen Li, Liwei Dong, Yaping Shan, Jintang Xie, Ting Song, Sai Zhang, Yun Kong, Shiqi Zhang, Chengwei Gu, Die Hu, Weijia Wang, Yunfan Yang* (2025). Paracrine stimulation of brown adipose tissue vascularization by adipocyte O-GlcNAc signaling; Cell Reports; 44(12):116678.
Yanjie Tan, Zhenzhou Huang, Yi Jin, Jiaying Wang, Hongjun Fan, Yangyang Liu, Liang Zhang, Yue Wu, Peiwei Liu, Tianliang Li, Jie Ran, He Tian, Sin Man Lam, Min Liu, Jun Zhou*, Yunfan Yang* (2024). Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice; Nature Communications; 15(1):8273.
Renjie Hong, Yanjie Tan, Xiaoyu Tian, Zhenzhou Huang, Jiaying Wang, Hua Ni, Jia Yang, Weiwen Bu, Song Yang, Te Li, Fan Yu, Weilong Zhong, Tao Sun, Xiaohong Wang, Dengwen Li, Min Liu, Yunfan Yang*, Jun Zhou* (2024). XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis; EMBO Reports; 25(3):1055-1074.
Song Yang, Fan Yu*, Mulin Yang, Hua Ni, Weiwen Bu, Hanxiao Yin, Jia Yang, Weishu Wang, Denghui Zhai, Xuemei Wu, Nan Ma, Te Li, Huijie Hao, Jie Ran, Ting Song, Dengwen Li, Sei Yoshida, Quanlong Lu*, Yunfan Yang*, Jun Zhou*, Min Liu* (2024). CYLD Maintains Retinal Homeostasis by Deubiquitinating ENKD1 and Promoting the Phagocytosis of Photoreceptor Outer Segments; Advanced Science; 11(45):e2404067.
Shuang Sun, Zhaoyang Xu, Haijie Hu, Manxi Zheng, Liang Zhang, Wei Xie, Lei Sun, Peiwei Liu, Tianliang Li, Liangran Zhang, Min Chen, Xueliang Zhu, Min Liu*, Yunfan Yang*, Jun Zhou* (2023). The Bacillus cereus toxin alveolysin disrupts the intestinal epithelial barrier by inducing microtubule disorganization through CFAP100; Science Signaling; 16(785):eade8111.
Yunfan Yang, Xiruo Li, Harding H Luan, Bichen Zhang, Kaisi Zhang, Jin Hyun Nam, Zongyu Li, Minnie Fu, Alexander Munk, Dongyan Zhang, Simeng Wang, Yuyang Liu, João Paulo Albuquerque, Qunxiang Ong, Rui Li, Qi Wang, Marie E Robert, Rachel J Perry, Dongjun Chung, Gerald I Shulman, Xiaoyong Yang*(2020). OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance; Proceedings of the National Academy of Sciences of the United States of America;117(28):16616-16625.
Yunfan Yang, Minnie Fu, Min-Dian Li, Kaisi Zhang, Bichen Zhang, Simeng Wang, Yuyang Liu, Weiming Ni, Qunxiang Ong, Jia Mi, Xiaoyong Yang* (2020). O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity; Nature Communications; 11(1):181.
Yunfan Yang, Jie Ran, Min Liu, Dengwen Li, Yuanyuan Li, Xingjuan Shi, Dan Meng, Junmin Pan, Guangshuo Ou, Ritu Aneja, Shao-Cong Sun, Jun Zhou* (2014). CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6; Cell Research; 24(11):1342-1353.
Yunfan Yang, Min Liu, Dengwen Li, Jie Ran, Jinmin Gao, Shaojun Suo, Shao-Cong Sun, Jun Zhou* (2014). CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation;Proceedings of the National Academy of Sciences of the United States of America; 111(6), 2158-2163.
社会兼职：
中国细胞生物学学会第四届青年工作委员会委员
山东细胞生物学学会第八届理事会理事
荣誉称号：
2009年获得南开大学优秀毕业生
2020年获得美国心脏协会职业发展奖励基金（1st place）
2022年获得山东省海外优青