姓名：廖旭东
职称：教授
邮箱：liaox@nankai.edu.cn
办公地址：南开大学生物站C208
研究方向：代谢与免疫的调控机制，及其在人类健康与疾病中的作用
教育背景与工作经历：
1994年-1998年，北京大学，学士学位；
1998年-2003年，中国医学科学院中国协和医学大学，博士学位；
2004年-2008年，美国Cleveland Clinic，博士后；
2008年-2011年，美国Case Western Reserve University，研究助理；
2012年-2015年，美国Case Western Reserve University，讲师；
2015年-2018年，美国Case Western Reserve University，助理教授；
2019年-至今，南开大学，教授。
研究成果：
主要从事心血管病分子机制研究。发现新的线粒体调控信号通路及其在心肌病中的应用。同时开展先天免疫系统调控心血管病的研究。近年来在国际主流杂志PNAS、Journal of Clinical Investigation等杂志发表论文30多篇，他引超过两千次。
代表性论文：
1. Pei Y, Ren D, Yin Y, Shi J, Ai Q, Hao W, Luo X, Zhang C, Zhao Y, Bai C, Zhu L, Wang Q, Li S, Zhang Y, Lu J, Liu L, Zhou L, Wu Y, Weng Y, Jing Y, Lu C, Cui Y, Zheng H, Li Y, Chen G, Hu G, Chen Q, Liao X. Endothelial FUNDC1 Deficiency Drives Pulmonary Hypertension. Circ Res. 2025 Jan 17;136(2):e1-e19. doi: 10.1161/CIRCRESAHA.124.325156. Epub 2024 Dec 10. PMID: 39655444.
2. Zhang Q, Sun T, Yu F, Liu W, Gao J, Chen J, Zheng H, Liu J, Miao C, Guo H, Tian W, Su M, Guo Y, Liu X, Pei Y, Wang Z, Chen S, Mu C, Lam SM, Shui G, Li Z, Yu Z, Zhang Y, Chen G, Lu C, Midgley AC, Li C, Bian X, Liao X, Wang Y, Xiong W, Zhu H, Li Y, Chen Q. PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury. Nat Chem Biol. 2024 Jul;20(7):835-846. doi: 10.1038/s41589-023-01528-7. Epub 2024 Jan 29. Erratum in: Nat Chem Biol. 2024 Jul;20(7):934. doi: 10.1038/s41589-024-01566-9. PMID: 38287154.
3. Zheng H, Liu J, Cheng Q, Zhang Q, Zhang Y, Jiang L, Huang Y, Li W, Zhao Y, Chen G, Yu F, Liu L, Li Y, Liao X, Xu L, Xiao Y, Zheng Z, Li M, Wang H, Hu G, Du L, Chen Q. Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance. Nat Cancer. 2024 Apr;5(4):572-589. doi: 10.1038/s43018-023-00715-8. Epub 2024 Jan 30. PMID: 38291304.
4. Liu Q, Xu C, Jin J, Li W, Liang J, Zhou S, Weng Z, Zhou Y, Liao X*, Gu A*. Early-life exposure to lead changes cardiac development and compromises long-term cardiac function. Sci Total Environ. 2023 Dec 15;904:166667. doi: 10.1016/j.scitotenv.2023.166667. PMID: 37652374.
5. Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen G, Li Y, Liao X, Shang Y, Hu G, Chen Q, Zhu Y. NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity. EMBO J. 2023 Aug 15;42(16):e113258. doi: 10.15252/embj.2022113258. PMID: 37409632.
6. Liu Q, Luo Q, Feng J, Zhao Y, Ma B, Cheng H, Zhao T, Lei H, Mu C, Chen L, Meng Y, Zhang J, Long Y, Su J, Chen G, Li Y, Hu G, Liao X, Chen Q, Zhu Y. Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression. eLife 11:e81247. doi: 10.7554/eLife.81247.
7. Sweet DR, Padmanabhan R, Liao X, Dashora HR, Tang X, Nayak L, Jain R, De Val S, Vinayachandran V, Jain MK. Krüppel-Like Factors Orchestrate Endothelial Gene Expression Through Redundant and Non-Redundant Enhancer Networks. J Am Heart Assoc. 2023 Feb 21;12(4):e024303. doi: 10.1161/JAHA.121.024303. Epub 2023 Feb 15. PMID: 36789992; PMCID: PMC10111506.
8. Liao X, Chang E, Tang X, Watanabe I, Zhang R, Jeong HW, Adams RH, Jain MK. Cardiac macrophages regulate isoproterenol-induced Takotsubo-like cardiomyopathy. JCI Insight. 2022 Feb 8;7(3):e156236. doi: 10.1172/jci.insight.156236. PMID: 35132957.
9. Zhang R, Hausladen A, Qian Z, Liao X, Premont RT, Stamler JS. Hypoxic vasodilatory defect and pulmonary hypertension in mice lacking hemoglobin β-cysteine93 S-nitrosylation. JCI Insight. 2022 Feb 8;7(3):e155234. doi: 10.1172/jci.insight.155234. PMID: 34914637.
10. Tang X, Wang P, Zhang R, Watanabe I, Chang E, Vinayachandran V, Nayak L, Lapping S, Liao S, Madera A, Sweet DR, Luo J, Fei J, Jeong HW, Adams RH, Zhang T*, Liao X*, Jain MK*. KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression. J Clin Invest. 2021 Nov 18:e147191. PMID: 34793333. *Corresponding author.
11. Zhu M, Zhang C, Zhang Z, Liao X, Ren D, Li R, Liu S, He X, Dong N. Changes in transcriptomic landscape in human end-stage heart failure with distinct etiology. iScience. 2022 Feb 17;25(3):103935. doi: 10.1016/j.isci.2022.103935. PMID: 35252820; PMCID: PMC8894266.
12. Zhou L, Lapping S, Liao X, Lu Y, Zhou G, Matoba K, Vasudevan NT, Wang L, Nayak L. The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-kappa B pathways (vol 15, e0241607, 2020). PLOS ONE 16.4 (2021).
13. Liu L, Li Y, Wang J, Zhang D, Wu H, Li W, Wei H, Ta N, Fan Y, Liu Y, Wang X, Wang J, Pan X, Liao X, Zhu Y, Chen Q. Mitophagy receptor FUNDC1 is regulated by PGC-1α/NRF1 to fine tune mitochondrial homeostasis. EMBO Rep. 2021 Mar 3;22(3):e50629. doi: 10.15252/embr.202050629. Epub 2021 Feb 8. PMID: 33554448; PMCID: PMC7926232.
14. Sweet DR, Vasudevan NT, Fan L, Booth CE, Keerthy KS, Liao X, Vinayachandran V, Takami Y, Tugal D, Sharma N, Chan ER, Zhang L, Qing Y, Gerson SL, Fu C, Wynshaw-Boris A, Sangwung P, Nayak L, Holvoet P, Matoba K, Lu Y, Zhou G, Jain MK. Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation. Nat Commun. 2020 Nov 18;11(1):5872. doi: 10.1038/s41467-020-19760-3. PMID: 33208733; PMCID: PMC7674440.
15. Zhou L, Lapping S, Liao X, Lu Y, Zhou G, Matoba K, Vasudevan N, Wang L, Nayak L. The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways. PLoS One. 2020 Nov 12;15(11):e0241607. doi: 10.1371/journal.pone.0241607. PMID: 33180821; PMCID: PMC7660536.