姓名：吴卫辉

职称：教授

邮箱：wuweihui@nankai.edu.cn

办公地址：南开大学生物楼216

研究方向：

主要致力于对细菌分子生物学和感染性疾病的研究，包括：

1. 铜绿假单孢菌耐药机理，致病基因表达调控；

2. 宿主的先天免疫中的信号传导；

3. 铜绿假单孢菌疫苗的研发。

教育背景与工作经历：

1994年-1998年，南开大学，学士学位；

1998年-2001年，南开大学，硕士学位；

2001年-2006年，美国佛罗里达大学，博士学位；

2006年-2009年，美国德克萨斯大学M.D.安德森癌症研究中心，博士后；

2009年-2011年，美国哈佛大学医学院布雷根及妇女医院Channing实验室，博士后；

2011年-至今，南开大学，生命科学学院，教授

研究成果：

天津市青年高层次人才项目、南开大学百名青年学术带头人入选者。从事病原细菌及免疫的研究，主要研究内容有：致病菌耐药机理研究；致病菌毒性基因的表达调控及作用机制；宿主在感染过程中的免疫反应。发现并阐明了一系列新型毒力因子、抗生素耐药及持留菌相关基因的功能和调控机制。近年来在国际主流杂志Nucleic Acids Res, mBio, Nature Communications等杂志发表论文50多篇。

代表论文

1.         Pan X, Liang H, Zhao X, Zhang Q, Chen L, Yue Z, Yin L, Jin Y, Bai F, Cheng Z, Bartlam M, Wu W. Regulatory and structural mechanisms of PvrA-mediated regulation of the PQS quorum-sensing system and PHA biosynthesis in Pseudomonas aeruginosa. (2023) Nucleic Acids Res. 2023 Feb 6:gkad059. doi: 10.1093/nar/gkad059.

2.         Chen H, Gong X, Fan Z, Xia Y, Jin Y, Bai F, Cheng Z, Pan X, Wu W. Pseudomonas aeruginosa Citrate Synthase GltA Influences Antibiotic Tolerance and the Type III Secretion System through the Stringent Response. (2023) Microbiol Spectr. e0323922.

3.         Long X, Wang X, Mao D, Wu W, Luo Y. A Novel XRE-Type Regulator Mediates Phage Lytic Development and Multiple Host Metabolic Processes in Pseudomonas aeruginosa. (2022) Microbiol Spectr. 10(6):e0351122.

4.         Gao C, Chen Y, Cheng X, Zhang Y, Zhang Y, Wang Y, Cui Z, Liao Y, Luo P, Wu W, Wang C, Zeng H, Zou Q, Gu J. A novel structurally identified epitope delivered by macrophage membrane-coated PLGA nanoparticles elicits protection against Pseudomonas aeruginosa. (2022) J Nanobiotechnology. 20(1):532

5.         Zhao X, Jin Y, Bai F, Cheng Z, Wu W, Pan X. Pseudomonas aeruginosa Phosphate Transporter PitA (PA4292) Controls Susceptibility to Aminoglycoside Antibiotics by Regulating the Proton Motive Force. (2022) Antimicrob Agents Chemother. 66(12):e0099222.

6.         Yang F, Zhou Y, Chen P, Cai Z, Yue Z, Jin Y, Cheng Z, Wu W, Yang L, Ha UH, Bai F. High-Level Expression of Cell-Surface Signaling System Hxu Enhances Pseudomonas aeruginosa Bloodstream Infection. (2022) Infect Immun. 90(10):e0032922.

7.         Long X, Zhang H, Wang X, Mao D, Wu W, Luo Y. RecT Affects Prophage Lifestyle and Host Core Cellular Processes in Pseudomonas aeruginosa. (2022) Appl Environ Microbiol. 88(18):e0106822.

8.         Gao J, Hu X, Xu C, Guo M, Li S, Yang F, Pan X, Zhou F, Jin Y, Bai F, Cheng Z, Wu Z, Chen S, Huang X, Wu W. Neutrophil-mediated delivery of the combination of colistin and azithromycin for the treatment of bacterial infection. (2022) iScience. 25(9):105035.

9.         Gao J, Wei X, Yin L, Jin Y, Bai F, Cheng Z, Wu W. Emergence and Transfer of Plasmid-Harbored rmtB in a Clinical Multidrug-Resistant Pseudomonas aeruginosa Strain. (2022) Microorganisms. 10(9):1818.

10.      Xu C, Wei X, Jin Y, Bai F, Cheng Z, Chen S, Pan X, Wu W. Development of Resistance to Eravacycline by Klebsiella pneumoniae and Collateral Sensitivity-Guided Design of Combination Therapies. (2022) Microbiol Spectr. 10(5):e0139022.

11.      Zhao X, Jin Y, Bai F, Cheng Z, Wu W, Pan X. Mutation of PA4292 in Pseudomonas aeruginosa Increases β-Lactam Resistance through Upregulating Pyocyanin Production. (2022) Antimicrob Agents Chemother. 66(7):e0042122.

12.      Li S, Gong X, Yin L, Pan X, Jin Y, Bai F, Cheng Z, Ha UH, Wu W. Acetylation of CspC Controls the Las Quorum-Sensing System through Translational Regulation of rsaL in Pseudomonas aeruginosa. (2022) mBio. 13(3):e0054722.

13.      Li H, Xia Y, Tian Z, Jin Y, Bai F, Cheng Z, Swietnicki W, Wu W, Pan X. Dihydrolipoamide Acetyltransferase AceF Influences the Type III Secretion System and Resistance to Oxidative Stresses through RsmY/Z in Pseudomonas aeruginosa. (2022) Microorganisms. 10(3):666.

14.      Pan X, Zhao X, Song Y, Ren H, Tian Z, Liang Q, Jin Y, Bai F, Cheng Z, Feng J, Wu W. Molecular Characterization of WCK 5222 (Cefepime/Zidebactam)-Resistant Mutants Developed from a Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate. (2022) Microbiol Spectr. 10(1):e0267821.

15.      Zhang X, Yin L, Liu Q, Wang D, Xu C, Pan X, Bai F, Cheng Z, Wu W, Jin Y. NrtR Mediated Regulation of H1-T6SS in Pseudomonas aeruginosa. (2022) Microbiol Spectr. 10(1):e0185821.

16.      Cai Z, Yang F, Shao X, Yue Z, Li Z, Song Y, Pan X, Jin Y, Cheng Z, Ha UH, Feng J, Yang L, Deng X, Wu W, Bai F. ECF Sigma Factor HxuI Is Critical for In Vivo Fitness of Pseudomonas aeruginosa during Infection. (2022) Microbiol Spectr. 10(1):e0162021.

17.      Yang B, Jiang Y, Jin Y, Bai F, Cheng Z, Wu W. Pseudomonas aeruginosa Oligoribonuclease Controls Susceptibility to Polymyxin B by Regulating Pel Exopolysaccharide Production. (2022) Antimicrob Agents Chemother. 66(3):e0207221.

18.      Wang D, Zhang X, Yin L, Liu Q, Yu Z, Xu C, Ma Z, Xia Y, Shi J, Gong Y, Bai F, Cheng Z, Wu W, Lin J, Jin Y. RplI interacts with 5' UTR of exsA to repress its translation and type III secretion system in Pseudomonas aeruginosa. (2022) PLoS Pathog. 18(1):e1010170.

19.      Duan N, Ma X, Cui H, Wang Z, Chai Z, Yan J, Li X, Feng Y, Cao Y, Jin Y, Bai F, Wu W, Rikihisa Y, Cheng Z. Insights into the mechanism regulating the differential expression of the P28-OMP outer membrane proteins in obligatory intracellular pathogen Ehrlichia chaffeensis. (2021) Emerg Microbes Infect. 10(1):461-471.

20.      Cebrián R, Xu C, Xia Y, Wu W, Kuipers OP. The cathelicidin-derived close-to-nature peptide D-11 sensitises Klebsiella pneumoniae to a range of antibiotics in vitro, ex vivo and in vivo. (2021) Int J Antimicrob Agents. 58(5):106434.

荣誉称号：

天津市青年高层次人才项目、南开大学百名青年学术带头人入选者

2020年获得唐立新优秀教学教师奖

2020年获得南开大学生命科学学院优秀本科课程奖

2008年获得“美洲华人生物科学学会德克萨斯州分会基础研究奖，二等奖”

2006年获得“美国佛罗里达大学优秀国际学生奖”

2005年获得“美国微生物协会优秀学生展牌奖”