刘定斌

发布者:王晨浏览次数:11

姓名:刘定斌

职称:教授

邮箱liudb@nankai.edu.cn

办公地址:天津市南开区卫津路94号南开大学中心实验室

课题组网页http://liulab.sklmcb.nankai.edu.cn/

研究方向

利用先进的分离富集技术助力肿瘤标志物筛选

发展高灵敏、高特异性的肿瘤检测探针

建立面向临床转化的体外诊断新方法


教育背景与工作经历:

2002-2006年,兰州大学,学士;

2006-2009年,中科院成都生物所,硕士;

2009-2012年,国家纳米科学中心,博士;

2012-2014年,美国国立卫生研究院,博士后;

2014年至今,南开大学化学学院,研究员、教授/博导。

研究成果:

近年来,已在生物医学检测和临床诊断领域发表论文110余篇,总影响因子>1000,论文他引7000余次,H因子43。近五年作为通讯作者在Proc. Natl. Acad. Sci. U.S.A.Sci. Adv.Nat. Commun.J. Am. Chem. Soc.Angew. Chem. Int. Ed.等国际知名刊物上发表论文40多篇,多篇论文被选为期刊封面、Hot PaperESI 高被引论文。申请中国专利12件,已授权9件,并实现7件专利的成果转化;主持科技部国家重点研发计划课题1项、国家自然科学基金杰出青年基金1项和面上项目5项(已结题3项)、军委后勤重点项目1项及多项横向课题。

代表性论文:

(1)  Qiang Li, Saisong Zhan, Xiaoqing Yang, Zhaowei Zhang, Ning Sun, Xiang Wang, Jingjing Kang, Rui Du, Xiaoqin Hong, Minghao Yue, Xiaomin Li, Yujing Tang, Guangming Liu, Yue Liu, and Dingbin Liu*, Choline Phosphate-Grafted Nanozymes as Universal Extracellular Vesicle Probes for Bladder Cancer Detection. ACS Nano, 2024, 18(25): 16113.

(2)  Moxuan Ji, Yongchun Wei, Zhuo Ye, Xiaoqin Hong, Xiaoxuan Yu, Rui Du, Qiang Li, Wei Sun, and Dingbin Liu*, In Vivo Fluorescent Labeling of Foam Cell-Derived Extracellular Vesicles as Circulating Biomarkers for In Vitro Detection of Atherosclerosis. Journal of the American Chemical Society, 2024, 146(14): 10093.

(3) Wenshuai Li, Jingqi Li, Hua Xu, Hongmei Gao and Dingbin Liu*, Rapid and visual identification of β-lactamase subtypes for precision antibiotic therapy. Nature Communications, 2024, 15: 719.

(4) Qiang Li, Zhaowei Zhang, Fengchao Wang, Xiang Wang, Saisong Zhan, Xiaoqing Yang, Chen Xu and Dingbin Liu*, Reversible Zwitterionic Coordination Enables Rapid, High-yield, and High-purity Isolation of Extracellular Vesicles from Biofluids. Science Advances, 2023, 9: eadf4568.

(5)  Zhiyou Zong, Xinzhuo Liu, Zhuo Ye, and Dingbin Liu*, A Double-switch pHLIP system enables Selective Enrichment of Circulating Tumor Microenvironment-derived Extracellular Vesicles. Proceedings of National Academy of Sciences of the United States of America, 2023, 120(2): e2214912120.

(6)  Zhaowei Zhang, Xuehui Liu, Xiaoqing Yang, Ying Jiang, Ang Li, Jiying Cong, Yuwei Li, Qinjian Xie, Chen Xu*, and Dingbin Liu*, Identification of Faecal Extracellular Vesicles as Novel Biomarkers for Non-invasive Diagnosis and Prognosis of Colorectal Cancer. Journal of Extracellular Vesicles, 2023, 12(1): 12300.

(7)  Wenshuai Li, Jingjing Wang, Chen Li, Zhiyou Zong, Jinzhong Zhao, Hongmei Gao, and Dingbin Liu*, Achieving Ultrasensitive Chromogenic Probes for Rapid, Direct Detection of Carbapenemase-Producing Bacteria in Sputum. JACS Au, 2023, 3(1): 227-238.

(8)  Fengchao Wang, Ning Sun, Qiang Li, Jie Yang, Xiaoqing Yang, and Dingbin Liu*, Self-Referenced Synthetic Urinary Biomarker for Quantitative Monitoring of Cancer Development. Journal of the American Chemical Society, 2023, 145(2): 919.

(9)  Zhuo Ye, Moxuan Ji, Kefeng Wu, Jie Yang, An-an Liu, Wei Sun, Dan Ding, and Dingbin Liu*, In-Sequence High-Specificity Dual-reporter Unlocking of Fluorescent Probe enables the Precise Identification of Atherosclerotic Plaques. Angewandte Chemie International Edition, 2022, 61(29); e202204518.

(10) Xinzhuo Liu, Zhiyou Zong, Mindan Xing, Xuehui Liu, Jia Li, and Dingbin  Liu*, pH-Mediated Clustering of Exosomes: Breaking Through the Size  Limit of Exosome Analysis in Conventional Flow Cytometry. Nano Letters, 2021, 21(20): 8817.


社会兼职:

Nanotheranostics》副主编

Targets》编委

《高等学校化学学报》青年编委

中国微米纳米技术学会微纳流控技术分会理事

中国研究型医院学会细胞外囊泡研究与应用专业委员会委员

中国生物材料学会体外诊断分会委员

中国感光学会光学传感与诊疗专业委员会委员

中国生物医学工程学会青年委员

中国抗癌协会青年委员

荣誉称号:

国家杰出青年科学基金获得者

国家“四青”人才