
姓名:曹林
职称:副教授
邮箱:1120140404@mail.nankai.edu.cn
办公地址:南开大学八里台校区生物站
教育背景与工作经历:
2014年至2018年,南开大学,博士;
2018年至2023年,南开大学,生命科学学院,博士后;
2023年至今,南开大学,生命科学学院,副教授。
研究成果:
主要利用结构生物学的方法研究与人类疾病相关病毒的感染和与宿主相互作用的生物学机制,为预防和治疗由病毒引起的相关疾病,设计优化工具病毒载体等方向提供理论基础和开辟新途径。成功解析了溶瘤病毒塞内加谷病毒与其受体、中和性抗体复合物的三维结构;不同血清型腺相关病毒与其对应受体的三维结构,为工具病毒在基因治疗方向上的应用提供了结构基础。
近五年内,共发表SCI研究性论文16篇。其中以第一作者(含共同第一作者)发表一区SCI论文6篇,接收二区SCI论文1篇,以共同通讯作者身份发表一区SCI论文1篇。以共同第一作者或共同通讯作者发表论文至今累计他引次数超过150次。
获得国家自然科学基金青年基金项目1项。入选第三批天津市青年人才托举工程。获得博士后第12批特别资助,获得博士后第64批面上资助。
代表性论文:
1.Lin Cao#; Zhang R#; Tingting Liu#; Zixian Sun#; Mingxu Hu; Yuna Sun; Lingpeng Cheng; Yu Guo; Sheng Fu; Junjie Hu; Xiangmin Li; Chengqi Yu; Hanyang Wang; Huanchun Chen; Xueming Li; Elizabeth E. Fry; David I. Stuart*; Ping Qian*; Zhiyong Lou*; ZiheRao, Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1, PNAS, 2018.12.18, 115(51): 13087~13092 (IF= 11.205)
2.Lin Cao#; Jizheng Chen#; Yaxin Wang; Yuting Yang; Jie Qing; ZiheRao; Xinwen Chen*; Zhiyong Lou*, Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy, Protein & Cell, 2018.3.1 4, 10(3): 178~195 (IF= 14.87)
3.Guobang Li#; Dan Fu#; Guangshun Zhang#; Dongming Zhao; Mingyu Li; XueGeng; Yuhui Wang; Cheng Chen; Peng Jiao; Lin Cao*; Yu Guo*; ZiheRao, Crystal structure of the African swine fever virus structural protein p35 reveals its role for core shell assembly, Protein & Cell, 2020 8;11(8):600-605 (IF= 14.87)
4.Ran Zhang#; Lin Cao#; Mengtian Cui#; Zixian Sun; Mingxu Hu; Rouxuan Zhang; William Stuart; Xiaochu Zhao; Zirui Yang; Xueming Li; Yuna Sun; Shentao Li; Wei Ding*; Zhiyong Lou*; Zihe Rao, Adeno-associated virus 2 bound to its cellular receptor AAVR, Nature Microbiology, 2019 Apr;4(4):675-682 (IF= 17.745)
5.Yiqing Yang#; Lin Cao#; Hongying Gao#; Yue Wu; Yaxin Wang; Fang Fang; Tianlong Lan; Zhiyong Lou*; Yu Rao*, Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors, J Med Chem, 2019 Apr 25;62(8):4056-4073 (IF= 7.4)
6.Ran Zhang#; GuangxueXu#; Lin Cao#; Zixian Sun#; Yong He; Mengtian Cui; Yuna Sun; Shentao Li; Huapeng Li; Lan Qin; Mingxu Hu; Zhengjia Yuan; ZipeiRao; Wei Ding; ZiheRao and Zhiyong Lou*, Divergent engagements between adeno-associated viruses with their cellular receptor AAVR, Nature Communications, 2019; 10: 3760 (IF= 14.919)
7.Zhao Z, Cao L, Sun Z, et al. A Structure-Guided Genetic Modification Strategy: Developing Seneca Valley Virus Therapy against Nonsensitive Nonsmall Cell Lung Carcinoma. J Virol. 2023;97(5):e0045923. doi:10.1128/jvi.00459-23
荣誉称号:
