姓名：Mark Bartlam
职称：教授
邮箱：bartlam@nankai.edu.cn
办公地址：天津市南开区卫津路94号南开大学药化生国重楼402
研究方向：
1.致病菌生物膜形成及调控机制
2.抗生素抗性基因传播机制
3．致病菌代谢关键蛋白质的结构与功能
教育背景与工作经历：
1992年9月-1995年8月，英国帝国理工大学，学士；
1995年9月-1999年12月，英国牛津大学，博士；
2000年1月-2003年8月，清华大学，外籍专家；
2003年9月-2007年9月，清华大学，副教授；
2007年10月-至今，南开大学，生命科学学院，教授。
研究成果：
Bartlam教授一直从事与重要人类疾病相关的蛋白质结构与功能，以及新型药物创制的研究。至今已解析140余个蛋白晶体结构，在Nature，Cell，PNAS，PLoS Biology, EMBO Journal，Nature Structural & Molecular Biology等国际顶尖级学术杂志上发表SCI论文140余篇，单篇引用率600余次。
代表性论文：
1. Che S., Chen Y., Liang Y., Zhang Q., Bartlam M. Crystal structure of RecR, a member of the RecFOR DNA-repair pathway, from Pseudomonas aeruginosa PAO1. (2018) Acta Crystallographica Section:F Structural Biology Communications, 74, pp. 222-230.
2. Wu, Z., Xie, M., Li, Y., Gao, G., Bartlam, M., Wang, Y. Biodegradation of decabromodiphenyl ether (BDE 209) by a newly isolated bacterium from an e-waste recycling area (2018) AMB Express, 8 (1), 27.
3. Wu, Z., Bartlam, M., Wang, Y.Complete genome sequence of Stenotrophomonas sp. strain WZN-1, which is capable of degrading polybrominated diphenyl ethers (2017) Genome Announcements, 5 (31), e00722-17.
4. Li, S., Teng, X., Su, L., Mao, G., Xu, Y., Li, T., Liu, R., Zhang, Q., Wang, Y., Bartlam, M. Structure and characterization of a NAD(P)H-dependent carbonyl reductase from Pseudomonas aeruginosa PAO1 (2017) FEBS Letters, 591 (12), pp. 1785-1797.
5. Xu, J., Wang, M., Sun, X., Ren, Q., Cao, X., Li, S., Su, G., Tuerhong, M., Lee, D., Ohizumi, Y., Bartlam, M., Guo, Y. Bioactive Terpenoids from Salvia plebeia: Structures, NO Inhibitory Activities, and Interactions with iNOS (2016) Journal of Natural Products, 79 (11), pp. 2924-2932.
6. Han, T., Zhao, Z., Bartlam, M., Wang, Y. Combination of biochar amendment and phytoremediation for hydrocarbon removal in petroleum-contaminated soil (2016) Environmental Science and Pollution Research, 23 (21), pp. 21219-21228.
7. Ji, Y., Postis, V.L.G., Wang, Y., Bartlam, M., Goldman, A. Transport mechanism of a glutamate transporter homologue GltPh (2016) Biochemical Society Transactions, 44 (3), pp. 898-904.
8. Hao, Z., Thomsen, M., Postis, V.L.G., Lesiuk, A., Sharples, D., Wang, Y., Bartlam, M., Goldman, A. A novel and fast purification method for nucleoside transporters (2016) Frontiers in Molecular Biosciences, 3 (JUN), 23.
9. Xu, J., Sun, X., Liu, X., Peng, M., Li, S., Jin, D.-Q., Lee, D., Bartlam, M., Guo, Y. Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells (2016) Journal of Functional Foods, 23, pp. 565-572.
10. Liu, J., Hao, Z., Ma, L., Ji, Y., Bartlam, M., Wang, Y. Spatio-temporal variations of high and low nucleic acid content bacteria in an exorheic river
(2016) PLoS ONE, 11 (4), e0153678.
11. Zhang, Q., Yan, D., Guo, E., Ding, B., Yang, W., Liu, R., Yamamoto, T., Bartlam, M. Structural basis for inhibition of the deadenylase activity of human CNOT6L (2016) FEBS Letters, 590 (8), pp. 1270-1279.
12. Ma, L., Mao, G., Liu, J., Gao, G., Zou, C., Bartlam, M.G., Wang, Y.Spatial-temporal changes of bacterioplankton community along an exhorheic river (2016) Frontiers in Microbiology, 7 (MAR), 论文编号 250, .
13. Ma, D., Hao, Z., Sun, R., Bartlam, M., Wang, Y. Genome sequence of a typical ultramicrobacterium, Curvibacter sp. strain PAE-UM, capable of phthalate ester degradation (2016) Genome Announcements, 4 (1), e01510-15.
14. Zhang, A., Guo, E., Qian, L., Tang, N.-Y., Watt, R.M., Bartlam, M. Purification, crystallization and X-ray crystallographic analysis of a putative exopolyphosphatase from Zymomonas mobilis(2016) Acta Crystallographica Section:F Structural Biology Communications, 72, pp. 172-178.
15. Bai, Y., Tashiro, S., Nagatoishi, S., Suzuki, T., Yan, D., Liu, R., Tsumoto, K., Bartlam, M., Yamamoto, T. Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach (2015) Protein and Cell, 6 (12), pp. 924-928.
社会兼职：
2016年至今，《Scientific Reports》期刊编辑
荣誉称号：
2017年，2016“外教中国”年度人物
2014年，天津市创新人才推进计划中青年科技创新领军人才
2012年，天津市国际科学技术合作奖
2011年，北京市科学技术奖
2011年，中华人民共和国国家友谊奖
2010年，天津市海河友谊奖
2010年 ，教育部新世纪优秀人才