姓名：杨雪
职称：研究员
研究方向：
受体信号偏向性与调控机制
基于结构的受体药理学
教育背景与工作经历：
2006年7月毕业于中国农业大学，获学士学位；
2012年6月毕业于南开大学生命科学学院，获博士学位。
研究成果：
聚焦神经精神疾病相关受体的结构与功能，围绕受体激活、信号转导偏向性及药理调控等问题，综合运用冷冻电镜结构生物学、药理学与细胞功能实验以及生物化学分析等方法，开展受体调控的分子机制研究。
代表性论文
Wen, T., Du, M., Lu, Y., Jia, N., Lu, X., Liu, N., Chang, S., Zhang, X., Shen, Y.*, and Yang, X.* (2025). Molecular basis of beta-arrestin coupling to the metabotropic glutamate receptor mGlu3. Nat Chem Biol21, 1262-1269. 10.1038/s41589-025-01858-8.
Lu, X., Li, D., Wang, Y., Zhang, G., Wen, T., Lu, Y., Jia, N., Wang, X., Chang, S., Zhang, X., Lin, J.*, Chen, Y.H.*, Yang, X.*, and Shen, Y.* (2025). Structural insights into the activation mechanism of the human zinc-activated channel. Nat Commun16, 442. 10.1038/s41467-024-55807-5.
Li, M., Li, Y., Lu, Y., Li, J., Lu, X., Ren, Y., Wen, T., Wang, Y., Chang, S., Zhang, X., Yang, X.*, and Shen, Y.* (2023). Molecular basis of Mg(2+) permeation through the human mitochondrial Mrs2 channel. Nat Commun14, 4713. 10.1038/s41467-023-40516-2.
Ren, Y., Li, Y., Wang, Y., Wen, T., Lu, X., Chang, S., Zhang, X., Shen, Y.*, and Yang, X.* (2022). Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel. J Biol Chem298, 101838. 10.1016/j.jbc.2022.101838.
Chen, X., Wang, Y., Li, Y., Lu, X., Chen, J., Li, M., Wen, T., Liu, N., Chang, S., Zhang, X., Yang, X.*, and Shen, Y.* (2022). Cryo-EM structure of the human TACAN in a closed state. Cell Rep38, 110445. 10.1016/j.celrep.2022.110445.
Wen, T., Wang, Z., Chen, X., Ren, Y., Lu, X., Xing, Y., Lu, J., Chang, S., Zhang, X., Shen, Y.*, and Yang, X.* (2021). Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor. Sci Adv7. 10.1126/sciadv.abg1483.
Ren, Y., Wen, T., Xi, Z., Li, S., Lu, J., Zhang, X., Yang, X.*, and Shen, Y.* (2020). Cryo-EM structure of the calcium homeostasis modulator 1 channel. Sci Adv6, eaba8161. 10.1126/sciadv.aba8161.
Xing, Y., Wang, M., Wang, J., Nie, Z., Wu, G., Yang, X.*, and Shen, Y.* (2019). Dimerization of MICU Proteins Controls Ca(2+) Influx through the Mitochondrial Ca(2+) Uniporter. Cell Rep26, 1203-1212 e1204. 10.1016/j.celrep.2019.01.022.
Liu, X., Wu, G., Yu, Y., Chen, X., Ji, R., Lu, J., Li, X., Zhang, X., Yang, X.*, and Shen, Y.* (2019). Molecular understanding of calcium permeation through the open Orai channel. PLoS Biol17, e3000096. 10.1371/journal.pbio.3000096.
Li, X., Wu, G., Yang, Y., Fu, S., Liu, X., Kang, H., Yang, X.*, Su, X.C.*, and Shen, Y.* (2017). Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers. Nat Commun8, 1042. 10.1038/s41467-017-01135-w.