姓名：王曼迪(Man-Di Wang)

职称：特聘研究员，博士生导师，课题组负责人

邮箱：wangmd@nankai.edu.cn

办公地址：南开大学津南校区综合实验楼C405-4

研究方向：多肽生物活性材料

教育背景与工作经历：

2013年9月-2017年6月，山东大学，学士

2017年9月-2022年6月，国家纳米科学中心（导师：王浩），博士

2022年9月-2025年9月，美国威斯康星麦迪逊分校（导师：Song Jin， Ying Ge），博士后

2025年9月至今，南开大学，特聘研究员，合作导师：杨志谋

研究成果：

课题组主要从事生物活性多肽材料的设计与应用研究，聚焦多肽自组装与功能调控，致力于发展新型多肽材料体系并拓展其在生物医学领域的应用。当前研究方向包括高稳定性多肽载体的构建、多肽经皮药物递送策略的开发、多肽用于肿瘤免疫治疗的设计以及抗菌肽的开发等。近年来，课题组在多肽材料与医学交叉领域取得了一系列研究成果，相关工作发表于Journal of the American Chemical Society、Angewandte Chemie、Advanced Science、Biomaterials等国际高水平期刊。

代表性论文

Man-Di Wang, Li Yi, Yanying Li, Ruiwen Xu, Jiaojiao Hu, Da-Yong Hou, Cong Liu*, Hao Wang*. Homologous Peptide Foldamer Promotes FUS Aggregation and Triggers Cancer Cell Death. Journal of the American Chemical Society, 2024, 146 (42): 28669-28676.

Man-Di Wang#, Gan-Tian Lv#, Hong-Wei An, Ni-Yuan Zhang and Hao Wang*. In Situ Self-Assembly of Bispecific Peptide for Cancer Immunotherapy. Angewandte Chemie International Edition, 2022, 61(10): e202113649.

Man-Di Wang#, Da-Yong Hou#, Gan-Tian Lv#, Ru-Xiang Li, Xing-Jie Hu, Zhi-Jia Wang, Ni-Yuan Zhang, Li Yi, Wan-Hai Xu* and Hao Wang*. Targeted in situ self-assembly augments peptide drug conjugate cell-entry efficiency. Biomaterials, 2021, 278: 121139.

Jun Li, Ziyu Jia, Dekun Li, Zhi-Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu,* Ling Wang,* Man-Di Wang*,CD28-Targeted Enzyme-Responsive Conformation-Switching Peptide Self-Assembly for Selective T-cell acute lymphoblastic leukemia (T-ALL) Therapy, Advanced Science, 2026, DOI:10.1002/advs.202520963

Xingjie Hu, Lihao Guo, Yinghao Ding, Shiyu Nie, Jingqi Fang, Jie Li, Quanhong Han, Dan Ding, Qian Zhang, Tingliang Wang, Ling Wang*; Mandi Wang*; Zhimou Yang*, Self-assembling peptide inspired by insulin and type 1 insulin-like growth factor for the treatment of androgenetic alopecia, Bioactive Materials, 2025, 53: 819-830

Da-Yong Hou#, Man-Di Wang#, Xing-Jie Hu#, Zhi-Jia Wang#, Ni-Yuan Zhang, Gan-Tian Lv, Jia-Qi Wang, Xiu-Hai Wu, Lu Wang, Hao Wang* and Wan-Hai Xu*. An activated excretion-retarded tumor imaging strategy towards metabolic organs. Bioactive Materials, 2022, 14: 110-119.

Man-Di Wang, Yu-Qing Huang and Hao Wang*. Handbook of Macrocyclic Supramolecular Assembly. Chapter: In Vivo Self-Assembly of Polypeptide-Based Nanomaterials, 2019,1023-1043.

Da-Yong Hou#, Ni-Yuan Zhang#, Man-Di Wang#, Shao-Xin Xu, Zhi-Jia Wang, Xing-Jie Hu, Gan-Tian Lv, Jia-Qi Wang, Xiu-Hai Wu, Lu Wang, Dong-Bing Cheng*, Hao Wang* and Wan-Hai Xu*. In Situ Constructed Nano-drug Depots through Intracellular Hydrolytic Condensation for Chemotherapy of Bladder Cancer. Angewandte Chemie International Edition, 2022, 61(18): e202116893.

Da-Yong Hou#, Man-Di Wang#, Ni-Yuan Zhang#, Shaoxin Xu#, Dong-Bing Cheng,* Taolei Sun,* Hao Wang,* and Wanhai Xu*, A Lysosome-Targeting Self-Condensation Prodrug-Nanoplatform System for Addressing Drug Resistance of Cancer, Nano Letters, 2022, 22(10): 3983-3992.

Gan-Tian Lv#, Qing-Hua Chen#, Man-Di Wang#, Xin-Wei Ye, Yi-Xuan Liu, Shan Liu, Qian-Ting Wang, Wen-Jia Lai, Pei-Pei Yang*, Hao Wang*, Inter-crosslinking peptide augments 4-1BB receptor clustering for cancer immunotherapy, Nano Today, 2023, 53: 102035. (IF: 16.9)

Xiu-Hai Wu#, Jia-Qi Wang#, Man-Di Wang#, Ting Xiao, Yu Wang, Jia-Yuan Niu, Lu Wang, Da-Yong Hou, Bo Fu, Zimo Liu, Hao Wang*, Wanhai Xu*, Bispecific fibrous glue synergistically boosts vascular normalization and antitumor immunity for advanced renal carcinoma therapy, Biomaterials, 2024, 308: 122550.

Hong-Wei An, Li-Li Li, Yi Wang, Ziqi Wang, Dayong Hou, Yao-Xin Lin, Sheng-Lin Qiao, Man-Di Wang, Chao Yang, Yong Cong, Yang Ma, Xiao-Xiao Zhao, Qian Cai, Wen-Ting Chen, Chu-Qi Lu, Wanhai Xu, Hao Wang, Yuliang Zhao. A tumour-selective cascade activatable self-detained system for drug delivery and cancerimaging. Nature Communication, 2019, 10(1), 4861.

Hong-Wei An, Muhetaerjiang Mamuti, Xiaofeng Wang, Haodong Yao, Man-Di Wang, Lina Zhao*, Li-Li Li*. Rationally Designed Modular Drug Delivery Platform Based on Intracellular Peptide Self-Assembly.Exploration, 2021, 1:20210153

Hong-Wei An, Yue Fei, Tong-Da Yan, Chu-Qi Lu, Man-Di Wang, Teng Ma, Bo-Yan Zhao, Jin-Mei Nie, Hsian-Rong Tseng, Li-Li Li*, and Hao Wang*. Gram-Positive Bacteria Cell Wall Driven Self-Disassembled anovesicles against Methicillin-Resistant Staphylococcus Aureus. Advanced Therapeutics, 2020, 3, 1900217

Hong-Wei An, Dayong Hou, Rui Zheng, Man-Di Wang, Xiang-Zhong Zeng, Wu-Yi Xiao, Tong-Da Yan, Jia-Qi Wang, Chang-Hao Zhao, Li-Ming Cheng, Jin-Ming Zhang, Lu Wang, Zi-Qi Wang, Hao Wang, Wanhai Xu. A Near-Infrared Peptide Probe with Tumor Specific Excretion-Retarded Effect for Image Guided Surgery of Renal Cell Carcinoma. ACS Nano, 2020, 14, 927-936

Wu-Yi Xiao, Yi Wang, Hong-Wei An, Dayong Hou, Muhetaerjiang Mamuti, Man-Di Wang, Jie Wang, Wanhai Xu, Liming Hu, Hao Wang. Click Reaction-Assisted Peptide Immune Checkpoint Blockade for Solid Tumor Treatment. ACS Applied Materials & Interfaces, 2020, 12, 40042-40051

Ziqi Wang, Hong‐Wei An, Dayong Hou, Man-Di Wang, Xiangzhong Zeng, Rui Zheng, Lu Wang, Keliang Wang, Hao Wang, Wanhai Xu, Addressable Peptide Self-Assembly on the Cancer Cell Membrane for Sensitizing Chemotherapy of Renal Cell Carcinoma. Advanced Materials, 2019, 31(11): 1807175.

Ziyu Wei, Yu Yi, Zhen Luo, Xiaoyun Gong, Yuxing Jiang, Dayong Hou, Li Zhang, Zimo Liu, Man-Di Wang, Jie Wang, Ruochen Guo, Jinjun Yang, Lei Wang, Hao Wang, Yuliang Zhao Selenopeptide nanomedicine activates natural killer cells for enhanced tumor chemoimmunotherapy. Advanced Materials, 2022, 34(17): 2108167.

Emily A Chapman, David S Roberts, Timothy N Tiambeng, Jãán Andrews, Man-Di Wang, Emily A Reasoner, Jake A Melby, Brad H Li, Donguk Kim, Andrew J Alpert, Song Jin, Ying Ge. Structure and dynamics of endogenous cardiac troponin complex in human heart tissue captured by native nanoproteomics.Nature Communication, 2023, 14, 8400

Xing‐Jie Hu, Ni‐Yuan Zhang, Da‐Yong Hou, Zhi‐Jia Wang, Man‐Di Wang, Li Yi, Zhang‐Zhi Song, Jian‐Xiao Liang, Xiang‐Peng Li, Hong‐Wei An, Wanhai Xu, Hao Wang, An In Vivo Self‐Assembled Bispecific Nanoblocker for Enhancing Tumor Immunotherapy. Advanced Materials, 2023, 35(45): 2303831.

Hong-Wei An, Da-Yong Hou, Jia Yang, Zi-Qi Wang, Man-Di Wang, Rui Zheng, Ni-Yuan Zhang, Xing-Jie Hu, Zhi-Jia Wang, Lu Wang, Di Liu, Jun-Feng Hao, Wanhai Xu, Yuliang Zhao, Hao Wang, A bispecific glycopeptide spatiotemporally regulates tumor microenvironment for inhibiting bladder cancer recurrence, Science Advances, 2023, 9(9): eabq8225.

社会兼职：

担任Journal of the American Chemical Society（JACS）独立审稿人

荣誉称号：

南开大学百名青年学科带头人(A类)

2025年国家级高层次青年人才