姓名：齐迹
职称：研究员
邮箱：qiji@nankai.edu.cn
办公地址：天津市海河教育园区同砚路38号南开大学综合实验楼C区
研究方向：
有机分子探针与高分辨率生物医学成像；
疾病靶向治疗干预与免疫微环境调控；
教育背景与工作经历：
2006年9月-2010年6月，浙江大学，学士学位；
2010年9月-2015年12月，中国科学院，博士学位；
2016年2月-2019年1月，香港科技大学，博士后；
2019年1月-2020年12月，哈佛大学医学院、麻省理工学院，博士后；
2020年12月-至今，南开大学，研究员、博导
研究成果：
通过调节分子探针的化学结构与能量转换过程，获得长波长高亮度的有机分子探针，用于重大疾病的早期诊断、调控解析与可视化治疗等。设计并研发高亮度长波长分子探针，实现高分辨率、大深度的活体成像与疾病进程原位监测；研发代谢标志物和细胞信号分子激活型分子探针，精准解析病灶微环境的异质性与动态性，揭示疾病调控过程和作用机制；构建分级靶向性诊疗一体化体系，用于多模态成像引导的协同免疫治疗，推动高效可视化治疗。
代表性论文：
Jianwen Song, Xiaoying Kang, Shuxuan Yang, Xue Meng, Zihang Shi, Wen Li*, Ji Qi*, A hierarchical theranostic nanoagent for multimodal imaging and targeted foam cell intervention in atherosclerosis. Nat. Commun. 2026, in press.
Pengcheng Zhang, Yi Jiang, Xueping Li, Yigang Xu, Tianxiang Geng, Fang Luo, Wen Li*, Xu Jin*, Ji Qi*, Multimodal Nanoregulator Rescues Impaired Neurovascular Units to Attenuate Secondary Injury Following Traumatic Brain Injury, Adv. Mater. 2026, 38, 09444.
Zhaoyun Liu*, Xiaohan Liu, Jingyi Ma, Yuan Zhang, Mengjie Ye, Hui Liu, Kai Ding, Jia Song, Rong Fu*, Ji Qi*, Harnessing Targeted Photodynamic Therapy to Synergistically Activate T Cell and NK Cell Responses in Multiple Myeloma, Adv. Mater. 2026, 38, e18663.
Mengyun Liang, Xiaoying Kang, Hanwen Liu, Lu Zhang, Tianjiao Wang, Mengjie Ye, Wen Li*, Ji Qi*, Ultrasound-Energized OX40L-Expressing Biohybrid for Multidimensional Mobilization of Sustained T Cell-Mediated Antitumor Immunity and Potent Sono-Immunotherapy, J. Am. Chem. Soc. 2025, 147, 13833−13850.
Jianwen Song, He Wang, Xue Meng, Wen Li, Ji Qi,* A hypoxia-activated and microenvironment-remodeling nanoplatform for multifunctional imaging and potentiated immunotherapy of cancer. Nat. Commun. 2024, 15, 10395.
Yuan Zhang, Dongfang Liu, Wenwen Chen, Yongyou Tao, Wen Li, Ji Qi*, Microenvironment-Activatable Probe for Precise NIR-II Monitoring and Synergistic Immunotherapy in Rheumatoid Arthritis. Adv. Mater. 2024, 36, 2409661.
Jianwen Song, Xiaoying Kang, Lu Wang, Dan Ding, Deling Kong*, Wen Li*, Ji Qi*, Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles. Nat. Commun. 2023, 14, 6881.
Yi Li, Xueping Li, Ting Chen, Jian Li, Ji Qi*, Wen Li*, A programmable platelet theranostic platform for adaptive multi-stage delivery and synergistic immunotherapy in atherosclerosis. Nat. Commun. 2025, 16, 6445.
Lu Zhang, Xiaoying Kang, Tianjiao Wang, Xuya Yu, Mengyun Liang, Junyan Jiang, Ji Qi*, Wen Li*, NO-Enhanced Sonodynamic Nanovesicles with Co-Stimulatory Molecule Self-Presentation for Multidimensional Tumor Immunotherapy. Angew. Chem. Int. Ed. 2025, 64, e202504684.
Xiaoying Kang, Wenwen Chen, Yuan Zhang, Jingyi Ma, Zekun Du, Xiaodong Chen, Ji Qi*, Zhimou Yang*, Xian Shen*, A Sono-Responsive Nanoplatform Integrating STING Activation and CXCR4 Blockade for Synergistic Immunotherapy of Glioblastoma, Adv. Mater. 2026, 38, e12104.
Xiaoying Kang, Yuan Zhang, Jianwen Song, Lu Wang, Wen Li*, Ji Qi*, Ben Zhong Tang*, A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy. Nat. Commun. 2023, 14, 5216.
Xue Meng, Jianwen Song, Zekun Du, Yongyou Tao, Ji Qi*, Microenvironment-Activatable Long-Wavelength NIR-II Visualization and Synergistic Treatment of Pulmonary Embolism. ACS Nano 2025, 19, 22454−22467.
Yuan Zhang, Xiaoying Kang, Jia Li, Jianwen Song, Xueping Li, Wen Li*, Ji Qi*, Inflammation-Responsive Nanoagents for Activatable Photoacoustic Molecular Imaging and Tandem Therapies in Rheumatoid Arthritis. ACS Nano 2024, 18, 2231–2249.
Yuan Zhang, Xiaoying Kang, Jingyi Ma, Jia Li, Wenwen Chen, Shuxuan Yang, Wen Li, Yang Shi*, Ji Qi*, Hierarchical Targeting Nanoplatform for NIR-II Photoacoustic Imaging and Photo-Activated Synergistic Immunotherapy of Glioblastoma. Adv. Funct. Mater. 2025, 35, 202419395.
Dongfang Liu, Mengyun Liang, Yongyou Tao, Hanwen Liu, Qian Liu, Wei Bing*, Wen Li*, Ji Qi*, Hypoxia-accelerating pyroptosis nanoinducers for promoting image-guided cancer immunotherapy. Biomaterials 2024, 309, 122610.
Yue Li, Zekun Du, Yuan Zhang, Xiaoying Kang, Jianwen Song, Xiaodong Chen, Yuanbo Hu, Zhimou Yang, Ji Qi*, Xian Shen*, Boosting Theranostic Performance of AIEgens Using Nanocatalyzer for Robust Cancer Immunotherapy. Adv. Funct. Mater. 2024, 34, 2315127.
Yi Li, Dongfang Liu, Ting Chen, Jianwen Song, Xuya Yu, Qian Liu, Ji Qi,* Wen Li,* Inhaled NIR‐II Nanocatalysts for Real‐Time Monitoring and Immunomodulatory Therapy of Acute Lung Injury. Adv. Funct. Mater. 2024, 34, 2403183.
Wen Meng, Ting Chen, Xueping Li, Yi Li, Lu Zhang, Yigang Xu, Tianqiang Song,* Ji Qi*, Qingqing Xiong*, Wen Li*, A Dual-Targeting Biomimetic Nanoplatform Integrates SDT/CDT/Gas Therapy to Boost Synergistic Ferroptosis for Orthotopic Hepatocellular Carcinoma Therapy. Adv. Sci. 2025, 12, 2413833.
Ting Chen, Wen Meng, Yi Li, Xueping Li, Xuya Yu, Ji Qi*, Dan Ding*, Wen Li*, Probiotics Armed with In Situ Mineralized Nanocatalysts and Targeted Biocoatings for Multipronged Treatment of Inflammatory Bowel Disease. Nano Lett. 2024, 24, 7321.
Xianshe Meng, Jianwen Song, Huawen Meng, Chenzhong Liao, Zequn Yin, Ke Gong, Deling Kong, Ji Qi*, Yajun Duan*, Microenvironment-activatable nanoagent for real-time NIR-II monitoring and targeted therapy of arterial restenosis. Biomaterials 2026, 324, 123482.
Ji Qi, Shaorui Jia, Xiaoying Kang, Xinying Wu, Yuning Hong, Ke Shan, Xianglong Kong, Zhiming Wang, Dan Ding*, Semiconducting Polymer Nanoparticles with Surface-Mimicking Protein Secondary Structure As Lysosome-Targeting Chimaeras for Self-Synergistic Cancer Immunotherapy. Adv. Mater. 2022, 34, 2203309.
Heqi Gao, Xingchen Duan, Di Jiao, Yi Zeng, Xiaoyan Zheng,* Jingtian Zhang, Hanlin Ou, Ji Qi,* Dan Ding,* Boosting Photoacoustic Effect via Intramolecular Motions Amplifying Thermal-to-Acoustic Conversion Efficiency for Adaptive Image-Guided Cancer Surgery. Angew. Chem. Int. Ed. 2021, 60, 21047.
社会兼职：
中国医药生物技术协会生物医学成像技术分会委员
中国生物材料学会神经修复材料分会委员
中国化学会生物医用材料化学专委会委员
荣誉称号：
2021年入选国家海外高层次引进人才青年项目；
2026年获得天津市自然科学二等奖