姓名：冯祖建
职称：副教授
邮箱：fzujian@nankai.edu.cn
办公地址：南开大学津南校区综合实验楼D区D120
研究方向：
生物医用高分子水凝胶
免疫调控生物材料与组织再生
心血管生物材料与植介入器械的开发与应用
教育背景与工作经历：
2011年9月-2015年7月，天津大学化工学院，化学工程与工艺，本科；
2015年9月-2021年6月，天津大学化工学院，生物医用高分子，硕博连读。
2021年7月-2024年12月，中国医学科学院生物医学工程研究所，助理研究员
2025年1月-至今，南开大学药物化学生物学全国重点实验室，副教授
研究成果：
主要从事仿生活性生物材料的设计构建与功能化，探索材料与免疫微环境互作机制及其组织修复效能。迄今为止，研究成果以第一/通讯作者在Advanced Functional Materials（3篇）、ACS Nano（1篇）、Biomaterials（3篇）、Bioactive Materials（2篇）、Advanced Science（4篇）等TOP期刊发表论文30余篇，总引用3000余次（h-index 28）。担任国际期刊《Materials Today Bio》、《View》和《Supramolecular Materials》青年编委。主持国家自然科学基金青年项目、天津市自然科学基金青年项目；参与国家自然科学基金面上项目、中国医学科学院医学与健康科技创新工程项目。获授权中国发明专利7项；以第二完成人获2023年天津市科学技术进步二等奖。
课题组立足临床问题，致力于构建新型生物材料体系与治疗策略，已搭建多个前沿交叉技术平台，包括微流控材料制备平台、类器官培养平台、基于临床样本的多组学/单细胞测序的多模态生物信息学分析平台，以及人工智能（AI）赋能的新材料设计平台，并于多家医院建立了深入的合作基础，为开展高水平、高质量研究提供坚实支撑。目前，课题组围绕“人工智能 + 类器官技术”驱动的生物材料前沿热点方向，诚邀对生物材料、免疫学、临床医学等交叉领域充满兴趣，具备较强学习能力与责任心的有志之士加入，共同学习、努力、成长！
代表性论文：
Yini Huangfu, Yiqun Zhang, Yufeng Zhang, Shuwei Wang, Sheng Ding, Rui Gao, Hang Li, Wenhao Ju*, Chuangnian Zhang, Pingsheng Huang*, Weiwei Wang*, Anjie Dong, Deling Kong, Zujian Feng*. Spatially heterogeneous microgel-annealed PRP-derived fibrin hydrogel promotes coordinated vasculogenesis and angiogenesis after myocardial infarction. Acta Biomaterialia, 2026, DOI: 10.1016/j.actbio.2026.02.012.
iomaterial design strategies for enhancing mitochondrial transplantation therapy. Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng*, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong*, Weiwei Wang*. BMEMat, 2025, DOI: 10.1002/bmm2.70046.
Yini Huangfu, Zhezhe Zhao, Xiang Liu, Jingrong Wang, Yufeng Zhang, Yonglan Wang, Chenxuan Wu*, Ju Zhang, Pingsheng Huang*, Chuangnian Zhang, Anjie Dong, Zujian Feng*, Weiwei Wang*. An off-the-shelf artificial blood clot hydrogel neutralizing multiple proinflammatory mediators for pro-regenerative periodontitis treatment. Advanced Science, 2025, e04106.
Qi Su, Jingrong Wang, Yini Huangfu, Rui Gao, Yu Gao, Huijuan Song*, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Zujian Feng*, Deling Kong, Weiwei Wang*. An off-the-shelf artificial pro-regenerative macrophage for pressure ulcer treatment. Advance Science, 2025, 12(21), 2415886.
Zhezhe Zhao, Chenxuan Wu, Yini Huangfu, Yufeng Zhang, Ju Zhang, Pingsheng Huang, Anjie Dong, Yonglan Wang, Jiayin Deng*, Weiwei Wang*, Zujian Feng*. Bioinspired Glycopeptide Hydrogel Reestablishing Bone Homeostasis through Mediating Osteoclasts and Osteogenesis in Periodontitis Treatment. ACS Nano 18 (43): 29507-29521.
Yushan Zhang, Yu Gao, Jingrong Wang, Rui Gao, Qi Su, Chuangnian Zhang, Pingsheng Huang, Weiwei Wang*, Zujian Feng*. Bioenergetic Metabolism Modulatory Peptide Hydrogel for Cardiac Protection and Repair After Myocardial Infarction. Advanced Functional Materials, 2024, 34(24): 2312772.
Jingrong Wang, Xiang Liu, Yaping Wang, Yushan Zhang, Rui Gao, Yu Gao, Pengxu Kong, Yini Huangfu, Chuangnian Zhang, Zujian Feng*, Pingsheng Huang, Pengxiang Yang*, Weiwei Wang*. Pro-Regenerative Glycopeptide Hydrogel Activates Type 2 Immune Response for Wound Healing via Macrophage-T Cell Crosstalk. Advanced Functional Materials, 2024, 34(16): 2307711.
Qinghua Li,# Huijuan Song,# Shuangyang Li, Pengbo Hu, Chuangnian Zhang, Ju Zhang, Zujian Feng*, Deling Kong, Weiwei Wang*, Pingsheng Huang*. Macrophage metabolism reprogramming EGCG-Cu coordination capsules delivered in polyzwitterionic hydrogel for burn wound healing and regeneration. Bioactive Materials, 2023, 29, 251-264.
Pengxu Kong, Jing Dong, Wenchao Li, Zefu Li, Rui Gao, Xiang Liu, Jingrong Wang, Qi Su, Bin Wen, Wenbin Ouyang, Shouzheng Wang, Fengwen Zhang, Shuyi Feng, Donglin Zhuang, Yongquan Xie, Guangzhi Zhao, Hang Yi, Zujian Feng*, Weiwei Wang*, Xiangbin Pan*. Extracellular Matrix/Glycopeptide Hybrid Hydrogel as an Immunomodulatory Niche for in situ Tissue Regeneration after Myocardial Infarction. Advanced Science, 2023, 10(23), 2301244.
Peng Zhao, Yu Zhang, Xiaoai Chen, Chang Xu, Jingzhe Guo, Meigui Deng, Xiongwei Qu, Pingsheng Huang*, Zujian Feng*, Jimin Zhang*. Versatile hydrogel dressing with skin adaptiveness and mild photothermal antibacterial activity for Methicillin-resistant Staphylococcus aureus-infected dynamic wound healing. Advanced Science, 2023, 10(11), 2206585.
Zujian Feng, Yumin Zhang, Chunfang Yang, Xiang Liu, Yini Huangfu, Chuangnian Zhang, Pingsheng Huang*, Anjie Dong, Jinjian Liu, Jianfeng Liu*, Deling Kong, Weiwei Wang*. Bioinspired and Inflammation‐modulatory Glycopeptide Hydrogels for Radiation‐induced Chronic Skin Injury Repair. Advanced Healthcare Materials, 2022, 12(1): 2201671.
Yaping Wang#, Jingrong Wang#, Rui Gao, Xiang Liu, Zujian Feng*, Chuangnian Zhang, Pingsheng Huang, Anjie Dong*, Deling Kong, Weiwei Wang*. Biomimetic glycopeptide hydrogel coated PCL/nHA scaffold for enhanced cranial bone regeneration via macrophage M2 polarization-induced osteo-immunomodulation, Biomaterials, 2022, 285: 121538.
Zujian Feng, Qi Su, Chuangnian Zhang, Pingsheng Huang, Huijuan Song, Anjie Dong*, Deling Kong*, and Weiwei Wang*. Bioinspired nanofibrous glycopeptide hydrogel dressing for accelerating wound healing: a cytokine-free, M2-type macrophage polarization approach. Advanced Functional Materials, 2020, 30(52): 2006454.