姓名：陈瑶
职称：教授
邮箱：chenyao@nankai.edu.cn
办公地址：天津市海河教育园区同砚路38号，南开大学津南校区综合实验楼B503
课题组网页：https://www.x-mol.com/groups/chen-yao
研究方向：陈瑶课题组长期致力于发展生物大分子固定化平台、新型生物医药材料及相关应用转化（如生物药、新型制剂及生物催化等），并对其生物安全性和相关机制进行深入探讨。
教育背景与工作经历：
2002年8月-2006年6月，青岛科技大学，学士学位；
2006年6月-2009年7月，南京工业大学，硕士学位；
2010年12月-2014年7月，南佛罗里达大学，博士学位；
2014年8月-2016年7月，加州大学圣地亚哥分校，博士后；
2016年7月-至今，南开大学，教授
研究成果：
先后主持国家优青（结题优秀）、天津市杰青、国家重点研发计划、国自然面上项目等国家/省部级项目十余项。近5年以通讯作者在Nat Synth、Nat Protoc、Nat Rev Chem、Nat Commun等高水平期刊发表论文49篇，累计他引超12000次，18篇论文入选ESI高被引。授权国际/国内发明专利20件（美国专利2件），并实现部分专利成果转化。获天津市科技进步特等奖、侯德榜化工科技青年奖、全球化工杰出青年女科学家奖、中国商业联合会科技进步一等奖、山东省科学技术进步一等奖等。
代表性论文：
Wang, Tonghai; Hao, Liqin; Wu, Shaochun; Lin, En; Wang, Kaiyuan; Wang, Jian; Liu, Yujie; Wang, Jiaxi; Michael J. Zaworotko; Cheng, Peng;Chen,Yao*; Zhang, Zhenjie*; Single-crystal one-dimensional porous covalent organic frameworks，Nat. Synth., 2026，Published online.
Qianqian Zhu, Yunlong Zheng, Zhenjie Zhang*, Yao Chen*, Enzyme Immobilization on Covalent Organic Framework Supports, Nat. Protoc., 2023, 18, 3080–3125
Jinjin Liu, Zhifang Wang, Peng Cheng, Michael Zaworotko, Yao Chen* and Zhenjie Zhang*, Post-Synthetic Modifications of Metal-Organic Cages, Nat. Rev. Chem. 2022, 6, 339-356.
Mingmin Li, Shan Qiao, Yunlong Zheng, Yassin H. Andaloussi, Xia Li, Zhenjie Zhang, Ang Li, Peng Cheng, Shengqian Ma, and Yao Chen*, Fabricate Covalent Organic Framework Capsules with Commodious Microenvironment for Enzymes, J. Am. Chem. Soc. 2020, 142, 6675.
Yunlong Zheng, Sainan Zhang, Jinbiao Guo, Ruixuan Shi, Jiangyue Yu, Kaipeng Li, NingLi, ZhenjieZhang, and Yao Chen*, Green and Scalable Fabrication of High-Performance Biocatalysts Using Covalent Organic Frameworks as Enzyme Carriers, Angew. Chem. Int. Ed. 2022, e202208744.
Zhengfeng Zhao+, Dong Zheng+, Menglei Guo, Jiangyue Yu, Sainan Zhang, Zhenjie Zhang, and Yao Chen*, Engineering Olefin-Linked Covalent Organic Frameworks for Photoenzymatic Reduction of CO2, Angew. Chem. Int. Ed. 2022, 61, e202200261.
Mingfang Yang, Xin Meng, Ruixuan Shi, Linglong Xie, Along Zuo, Lijie Wang, Jinbiao Guo, Yingxiao Sun, Jiangyue Yu, Zeyan Di, Zhenjie Zhang & Yao Chen *. Multicomponent synergistic immobilization via in-situ and dynamic exchange strategies for constructing hierarchical biopharmaceuticals. Nat. Commun (2026). Published online.
Qianqian Zhu, Yunlong Zheng, Jiangyue Yu, Jin Li, Heng Hu, Zhifang Wang, Qiongyu Shi, Zhenjie Zhang and Yao Chen*, Biomimetic transmembrane transport of multi-enzymes to fabricate heterogeneous bioreactors with photoenzymatic reduction of CO2. Nat. Commun 2025, 16, 11254 .
Jinbiao Guo, Xiaoyu Sun, Jian Wang, Yimiao Hou, Mingfang Yang, Junjie Tan, Zhenjie Zhang, Yao Chen*, Wen Chen, Precise modulation of protein refolding via tailored microenvironments of confined space, Nat. commun., 2025. 16, 4122.
Zhu Q, Dong P., Yu J., Wang Z., Wang T., Qiao S., Liu J., Geng S., Zheng Y., Cheng P., Zaworotko M.J.,* Zhang Z.*, and Chen Y.*. COF cap2: a Recyclable Tandem Catalysis Reactor for Nitrogen Fixation and Conversion to Chiral Amines, Nat. commun., 2025, 16, 992.
Dong Zheng, Yunlong Zheng, Junjie Tan, Zhenjie Zhang, He Huang, and Yao Chen*. Co-immobilization of whole cells and enzymes by covalent organic framework for biocatalysis process intensification, Nat. commun., 2024, 15, 5510.
Shan Qiao, Yingxiao Sun, Kaiyuan Wang, Shuo Zhou,En Lin,Along Zuo,Xin Liu,Jiangyue Yu,Zhenjie Zhang,and Yao Chen*, Dynamic Exchange Assembly of Enzymes with Single-Crystal Covalent Organic Frameworks, J. Am. Chem. Soc. 2026, 148, 9, 9892-9900.
Hongde An, Jie Song, Ting Wang, Nannan Xiao, Zhenjie Zhang, Peng Cheng, Shengqian Ma, He Huang, Yao Chen*, Metal-Organic Framework Disintegrants: Enzyme Preparation Platforms with Boosted Activity, Angew. Chem. Int. Ed. 2020, 59, 16764-16769.
Yuanyuan Li, Jinhui Yang, Haoyan Zhang, Zhengfeng Zhao*, Mingxu Wang, Yao Chen*,. Engineering Amino Acid Functionalized Chiral Carbon-Organic Frameworks for Enhanced Photocatalytic Hydrogen Production, Angew. Chem. Int. Ed. 2026, Published online.
Jian Wang, Chaonan Jin, Sa Wang,8 Yingxiao Sun, Ting Wang,8 Xiaotong Yu, Jinxia Wei,* Zhenjie Zhang,* Yubo Li* and Yao Chen*, A Scalable COF-Based Sequestrant for Synergistic Bile Acid Modulation in Fatty Liver Disease, J. Am. Chem. Soc. (2026).
Mingfang Yang, Yunlong Zheng, Yuqing Cai, Jinbiao Guo, Along Zuo, Jiangyue Yu, Sainan Zhang, Zhenjie Zhang, and Yao Chen*. Highly Efficient Chiral Separation Based on Alkali-proof Protein Immobilization by Covalent Organic Frameworks, Angew. Chem. Int. Ed. 2024, e202420269.
Liqin Hao, Qianqian Zhu, Xueling Qiao, Qiongyu Shi, Yujie Liu, Tonghai Wang, En Lin, Cheng Peng, Zhenjie Zhang, Yao Chen*. Fast Production of Covalent Organic Frameworks for Covalent Enzyme Immobilization with Boosted Enzymatic Catalysis by Solar-Driven Photothermal Effect, Angew. Chem. Int. Ed. 2024, e202416550.
Yubo Li*, Jinxia Wei, Jian Wang, Yuanyuan Wang, Peishuang Yu,Yao Chen*, Zhenjie Zhang*.Covalent organic frameworks as superior adsorbents for the removal of toxic substances. Chem. Soc. Rev. 2025,54, 2693-2725
Wenjie Duan, Shan Qiao, Mingjing Zhuo, Jiaxing Sun, Menglei Guo, Fei Xu, Jinjin Liu, Ting Wang, Xiuxiu Guo, Yan Zhang, Jia Gao, Yueyun Huang, Zhenjie Zhang, Peng Cheng, Shengqian Ma*, Yao Chen*, Multifunctional Platforms: Metal-Organic Frameworks for Cutaneous and Cosmetic Treatment, Chem. 2021, 7, 450-462.
Shan Qiao, Haiqun Jin, Along Zuo, and Yao Chen*, Integration of Enzyme and Covalent Organic Frameworks: From Rational Design to Applications, Acc. Chem. Res. 2024, 57, 1, 93–105
社会兼职：
中国化工学会理事
中国化工学会女科技工作者委员会委员
中国医药生物技术学会生物制药技术分会委员
天津市青年联合会副主席
中国化工学会生物化工专委会委员
Chinese Chemical Letters期刊编委
荣誉称号：
2020年获得国家优秀青年科学基金项目（国家优青）
2023年获得天津市杰出青年科学基金项目（天津杰青）
2023年获得侯德榜化工科学技术青年奖
2023年获得全球华人化工女科学奖
2025年获得天津市科学技术进步奖特等奖
2025年获得中国商业联合会科技进步奖一等奖
2025年获得山东省科学技术奖一等奖
2022年获得天津市优秀科技工作者