姓名：刘林
职称：教授
办公地址：天津市南开区卫津路南开大学生物站C301
课题组网页：liulin.nankai.edu.cn
研究方向：1、端粒调控干细胞衰老与再生的新途径及机制；
2、卵巢衰老机制与干预的新策略。
教育背景与工作经历：
1980-1984，江西农业大学，动物科学获学士学位
1984-1987，江西农业大学，动物生理生化硕士学位
1990-1993，中国农业大学，动物繁殖与生物技术博士学位
1994-1996，剑桥Babraham研究所，访问学者
1996-1998，康奈尔大学、康州大学，博士后
1998-2004，布朗大学，助理教授
2003-2007，中山大学，教授
2007-至今，南开大学，教授
研究成果：
优化克隆技术多个步骤，尤其是卵子激活，提高了动物克隆效率；揭示了卵巢衰老卵子质量和数量下降的机理，提供延缓卵巢衰老的有效途径及重建卵巢功能的新策略；阐明端粒及再生调控干细胞多能性的机制，及发现端粒在受精后迅速延长的现象，对于胚胎发育和个体衰老的重要意义等。发表在包括Nature Biotechnology, Nature Cell Biology, Nature, Nature Communications, Developmental Cell, PNAS, Cell Rep, Human Reproduction等SCI论文180余篇，参编8部英文专著章节，文章被引用9000余次。连续9年入选Elsevier “中国高被引学者”榜单。
代表性论文：
1、Panpan Shi, Xukun Lu, Kairang Jin, Linlin Liu, Guoxing Yin, Wenying Wang, Jiao Yang, Lijuan Wang, Lijun Dong, Wei Xie, Lin Liu. USP17L promotes the 2-cell-like program through deubiquitination of H2AK119ub1 and ZSCAN4. Nat Commun. 2025 Aug 1;16(1):7071. doi: 10.1038/s41467-025-62303-x.
2、Guofeng Feng, Guoxing Yin, Yusheng Liu, Chang Liu, Jie Li, Jiangtao Lu, Yongqin Yu, Ziyi Jin, Yiwei Wu, Yanbin Yue, Xiufang Gao, Jiaqiang Wang, Falong Lu, Lin Liu. Nat10 maintains the homeostasis of pluripotent and 2-cell-like states in mouse embryonic stem cells through mRNA cytidine acetylation. Nucleic Acids Res. 2025 Jun 6;53(11):gkaf504. doi: 10.1093/nar/gkaf504.
3、Jiao Yang, Jiameng Dan, Nannan Zhao, Linlin Liu, Huasong Wang, Qiangqiang Liu, Lingling Wang, Jie Li, Yiwei Wu, Feilong Chen, Weilun Fu, Fei Liu, Meiqi Lin, Weiyu Zhang, Fuquan Chen, Xinqi Liu, Xinyi Lu, Quan Chen, Xudong Wu, Yuyu Niu, Na Yang, Yushan Zhu, Jiafu Long, and Lin Liu. Zscan4 mediates ubiquitination and degradation of co-repressor complex to promote chromatin accessibility in 2C-like cells. Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2407490121.
4、Niannian Li, Kairang Jin, Bin Liu, Mingzhu Yang, PanPan Shi, Dai Heng, Jichang Wang, Lin Liu. Single-cell 3D genome structure reveals distinct human pluripotent states. Genome Biol. 2024 May 13;25(1):122.
5、Xinyi Lu, Lin Liu. Genome stability from the perspective of telomere length. Trends Genet. 2024 Feb;40(2):175-186.
6、Chenglei Tian, Jing Wang, Xiaoying Ye, Jiyu Chen, Rongyan Zheng, Hanwen Yu, Jie Li, Guoxing Yin, Linlin Liu, Nannan Zhao, Guofeng Feng, Zhengmao Zhu, Jichang Wang, Guoping Fan, Lin Liu. ESCs culture conditions impact the tumor appearance in vivo. Cell Rep. 2023 Jun 13;42(6):112645.
7、Nannan Zhao, Guoxing Yin, Chun Liu, Weiyu Zhang, Yang Shen, Dan Wang, Zhenzhen Lin, Jiao Yang, Jian Mao, Renpeng Guo, Yongwang Zhang, Feng Wang, Zhe Liu, Xinyi Lu, Lin Liu. Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells. Cell Discov. 2023 May 2;9(1):45.
8、Haifeng Fu, Weiyu Zhang, Niannian Li, Jiao Yang, Xiaoying Ye, Chenglei Tian, Xinyi Lu and Lin Liu. Elevated retrotransposon activity and genomic instability in primed pluripotent stem cells. Genome Biol. 2021 Jul 9;22(1):201.
9、Hua Wang, Peng Gong, Tong Chen, Shan Gao, Zhenfeng Wu, Xiaodong Wang, Jie Li, Sadie L. Marjani, José Costa, Sherman M. Weissman,Feng Qi,Xinghua Pan, and Lin Liu. Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single-Cell analysis of Transcriptome and Telomeres. Adv Sci (Weinh). 2021 Feb 8;8(8):2004320.
10、Dai Heng, Xiaoyan Sheng, Chenglei Tian, Jie Li, Linlin Liu, Mo Gou, Lin Liu. Mtor inhibition by INK128 extends functions of the ovary reconstituted from germline stem cells in aging and premature aging mice. Aging Cell. 2021 Feb;20(2): e13304.
11、Chenglei Tian , Linlin Liu , Xiaoying Ye , Haifeng Fu , Xiaoyan Sheng , Lingling Wang , Huasong Wang , Dai Heng , Lin Liu . Functional Oocytes Derived from Granulosa Cells. Cell Reports. Cell Rep. 2019 Dec 24;29(13):4256-4267.e9.
12、Weiyu Zhang , Fuquan Chen , Ruiqing Chen , Dan Xie , Jiao Yang , Xin Zhao , Renpeng Guo , Yongwang Zhang , Yang Shen , Jonathan Göke , Lin Liu , Xinyi Lu . Zscan4c activates endogenous retrovirus MERVL and cleavage embryo genes. Nucleic Acids Res. 2019 Sep 19;47(16):8485-8501.
13、Renpeng Guo , Xiaoying Ye , Jiao Yang , Zhongcheng Zhou , Chenglei Tian , Hua Wang , Haiying Wang , Haifeng Fu , Chun Liu , Ming Zeng , Jun Yang , Lin Liu . Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells. Nature Communications. 9(1):2620 (2018).
14、Haifeng Fu , Cheng-Lei Tian , Xiaoying Ye , Xiaoyan Sheng , Hua Wang , Yifei Liu , Lin Liu . Dynamics of Telomere Rejuvenation during Chemical Induction to Pluripotent Stem Cells. Stem Cell Reports. 11(1):70-87(2018).
15、Zhongcheng Zhou, Lingling Wang , Feixiang Ge , Peng Gong , Hua Wang , Feng Wang , Lingyi Chen, Lin Liu . Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis. Nucleic Acids Res. 46(7):3468-3486(2018).
16、Lin Liu. Linking Telomere Regulation to Stem Cell Pluripotency. Trends in Genetics 33（1）: 16-33 (2017)
17、Jiao Yang, Renpeng Guo, Hua Wang, Xiaoying Ye, Zhongcheng Zhou, Jiameng Dan, Haiying Wang, Peng Gong, Wei Deng, Yu Yin, Shiqing Mao, Lingbo Wang, Junjun Ding, Jinsong Li, David L. Keefe, Meelad M. Dawlaty, Jianlong Wang, GuoLiang Xu, and Lin Liu. Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs. Cell Reports 15(8):1809-21 (2016).
18、Haixia Chen , Renpeng Guo , Qian Zhang , Hongchao Guo , Meng Yang , Zhenfeng Wu , Shan Gao , Lin Liu , Lingyi Chen . Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. PNAS 112(44):E5936-43(2015).
19、Li-Ying Sung , Wei-Fang Chang , Qian Zhang , Chia-Chia Liu , Jun-Yang Liou , Chia-Chun Chang , Huan Ou-Yang , Renpeng Guo , Haifeng Fu , Winston T K Cheng , Shih-Torng Ding , Chuan-Mu Chen , Maja Okuka , David L Keefe , Y Eugene Chen , Lin Liu , Jie Xu . Telomere elongation and naïve pluripotent stem cells achieved from telomerase haplo-insufficient cells by somatic cell nuclear transfer. Cell Reports 9:1603–1609 (2014).
20、Jiameng Dan , Yifei Liu , Na Liu , Maria Chiourea , Maja Okuka , Tao Wu , Xiaoying Ye , Chunlin Mou , Lei Wang , Lingling Wang , Yu Yin , Jihong Yuan , Bingfeng Zuo , Fang Wang , Zhiguo Li , Xinghua Pan , Zhinan Yin , Lingyi Chen , David L Keefe , Sarantis Gagos , Andrew Xiao , Lin Liu . Rif1 maintains telomere length homeostasis of ES cells by mediating heterochromatin silencing. Developmental Cell 29: 7–19 (2014).
21、Jihong Yuan , Dongdong Zhang, Lei Wang, Mengyuan Liu, Jian Mao, Yu Yin, Xiaoying Ye, Na Liu, Jihong Han, Yingdai Gao, Tao Cheng, David L Keefe, Lin Liu. No evidence for neo-oogenesis may link to ovarian senescence in adult monkey. Stem Cells 31:2538-2550 (2013).
22、Fang Wang , Xinghua Pan, Keri Kalmbach, Michelle L Seth-Smith, Xiaoying Ye, Danielle M F Antumes, Yu Yin, Lin Liu, David L Keefe, Sherman M Weissman. Robust measurement of telomere length in single cells. Proc Natl Acad Sci USA. 110:E1906-1912 (2013).
23、Jing Jiang , Wenjian Lv, Xiaoying Ye, Lingbo Wang, Man Zhang, Hui Yang, Maja Okuka, Chikai Zhou, Xuan Zhang, Lin Liu, Jinsong Li. Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation. Cell Research 23:92-106 (2013).
24、Yi Liu , Xiaoying Ye, Lina Mao, Zhaokang Cheng, Xinpeng Yao, Xiaohua Jia, Duo Mao, Lailiang Ou, Zongjin Li, Yongzhe Che, Na Liu, Gustav Steinhoff, Lin Liu, Deling Kong. Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction. Cardiovascular Research 97:208-218 (2013).
25、Mengyuan Liu , Yu Yin, Xiaoying Ye, Ming Zeng, Qiang Zhao, David L Keefe, Lin Liu. Resveratrol protects against age-associated infertility in mice. Human Reproduction 28:707-717 (2013).
25、Fang Wang , Yu Yin, Xiaoying Ye, Kai Liu, Haiying Zhu, Lingling Wang, Maria Chiourea, Maja Okuka, Guangzhen Ji, Jiameng Dan, Bingfeng Zuo, Minshu Li, Qian Zhang, Na Liu, Lingyi Chen, Xinghua Pan, Sarantis Gagos, David L Keefe, Lin Liu. Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells. Cell Research 22:757-768 (2012).
26、Jinmiao Liu , Mengyuan Liu, Xiaoying Ye, Kai Liu, Junjiu Huang, Lingling Wang, Guangzhen Ji, Na Liu, Xiangdong Tang, Jay M Baltz, David L Keefe, Lin Liu. Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC). Hum Reproduction 27:1411-2140 (2012).
27、Zhong Liu , Zhe Hu, Xinghua Pan, Minshu Li, Taiwo A Togun, David Tuck, Mattia Pelizzola, Junjiu Huang, Xiaoying Ye, Yu Yin, Mengyuan Liu, Chao Li, Zhisheng Chen, Fang Wang, Lingjun Zhou, Lingyi Chen, David L Keefe, Lin Liu. Germline competency of parthenogenetic embryonic stem cells from immature oocytes of adult mouse ovary. Human Molecular Genetics 20: 1339-1352 (2011).
28、Junjiu Huang , Fang Wang, Maja Okuka, Na Liu, Guangzhen Ji, Xiaoying Ye, Bingfeng Zuo, Minshu Li, Ping Liang, William W Ge, John Cm Tsibris, David L Keefe, Lin Liu. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Research 21:779-792 (2011).
29、Suneet Agarwal , Yuin-Han Loh, Erin M McLoughlin, Junjiu Huang, In-Hyun Park, Justine D Miller, Hongguang Huo, Maja Okuka, Rosana Maria Dos Reis, Sabine Loewer, Huck-Hui Ng, David L Keefe, Frederick D Goldman, Aloysius J Klingelhutz, Lin Liu, George Q Daley, Daley GQ. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature 464:292-296 (2010).
30、Junjiu Huang , Maja Okuka, Fang Wang, Bingfeng Zuo, Ping Liang, Keri Kalmbach, Lin Liu, David L Keefe. Generation of pluripotent stem cells from eggs of aging mice. Aging Cell 9:113-125 (2010).
31、Chao Li , Zhisheng Chen, Zhong Liu, Junjiu Huang, Wei Zhang, Lingjun Zhou, David L Keefe, Lin Liu. Correlation of expression and methylation of imprinted genes with pluripotency of parthenogenetic embryonic stem cells. Human Molecular Genetics 18:2177-2187 (2009).
32、Zhisheng Chen , Zhong Liu, Junjiu Huang, Tomokazu Amano, Chao Li, Shanbo Cao, Chao Wu, Bodu Liu, Lingjun Zhou, Mark G Carter, David L Keefe, Xiangzhong Yang, Lin Liu. Birth of Parthenote mice directly from parthenogenetic embryonic stem cells. Stem Cells 27:2136-2145 (2009).
33、Junjiu Huang , Kai Deng, Haojia Wu, Zhong Liu, Zhisheng Chen, Shanbo Cao, Lingjun Zhou, Xiaoying Ye, David L Keefe, Lin Liu. Efficient production of mice from embryonic stem cells injected into four- or eight-cell embryos by piezo micromanipulation. Stem Cells 26:1883-1890 (2008)
34、Lin Liu , Susan M Bailey, Maja Okuka, Purificación Muñoz, Chao Li, Lingjun Zhou, Chao Wu, Eva Czerwiec, Laurel Sandler, Andreas Seyfang, Maria A Blasco, David L Keefe. Telomere lengthening early in development. Nature Cell Biology 9: 1436-1441 (2007)
35、Lin Liu , Sonia Franco, Barbara Spyropoulos, Peter B Moens, Maria A Blasco, David L Keefe. Irregular telomeres impair meiotic synapsis and recombination in mice. Proc Natl Acad Sci U S A 101: 6496-6501 (2004)
36、Lin Liu , Maria A Blasco, David L Keefe. Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindles. EMBO Reports 3:230-234 (2002)
37、Lin Liu , James R Trimarchi, Peter J S Smith, David L Keefe. Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell 1:40-46 (2002)
38、Lin Liu. Cloning efficiency and differentiation. Nature Biotechnology 19:406 (2001) (Correspondence).
39、Lin Liu , R Oldenbourg, J R Trimarchi, D L Keefe. A reliable, noninvasive technique for spindle imaging and enucleation of mammalian oocytes. Nature Biotechnology 18: 223 – 225 (2000)
社会兼职：
中国细胞生物学会干细胞生物学分会委员
中国细胞生物学会衰老细胞生物学分会委员
中国细胞学会发育生物学分会委员
Precision Clinical Medicine 编委
Frontiers in Oncology( Cancer Molecular Targets and Therapeutics) 编委
Signal Transduction and Targeted Therapy 编委
荣誉称号：
2003，长江学者特聘教授
2003，美国生殖医学会辅助生殖技术奖一等奖，Short telomeres in the chromosomes of spare eggs predict poor prognosis following in vitro fertilization/embryo transfer-toward a telomere theory of reproductive aging in women
2004，国家杰出青年基金
2011，国家教育部高等学校科技进步奖二等奖，青春期妇科内分泌相关问题的临床与实验研究
2012，广东省科学技术奖二等奖
2012，南开大学教学成果奖，细胞生物学教学创新体系的建立与实践
2014，第五届中国侨界（创新人才）贡献奖
2014，天津市创新人才推进计划重点领域创新团队
2014，国家百千万人才工程“有突出贡献中青年专家”
2023，高等学校科学研究优秀成果奖（科学技术）二等奖，卵巢衰老机制及功能重建新策略