姓名：孙宝发
职称：研究员
邮箱：sunbf@nankai.edu.cn
办公电话：13366061070
课题组网页：https://sky.nankai.edu.cn/sbf/list.htm
教育背景与工作经历：
2009年9月-2013年3月，中国科学院大学，理学博士学位；
2013年7月-2015年12月，中国科学院北京基因组研究所，助理研究员
2016年1月-2021年5月，中国科学院北京基因组研究所，副研究员
2021年5月-至今，南开大学生科院，研究员
研究成果：
课题组致力于通过单细胞及表观多组学进行多种生物学过程的调控机制解析。系统揭示了RNA修饰调控RNA出核、剪接、翻译及稳定性等的分子机制，阐明了RNA修饰在多种生理（发育、神经、生殖、再生等）及病理（肿瘤、肥胖、动脉粥样硬化等）的作用机理；同时通过单细胞组学解析了胰腺癌、肿瘤免疫、盆腔脱垂、心脏疾病及神经疾病等发生的分子机制。近年来在Nature，Nature Immunology，Science Immunology，Nature Cell Biology，Science Translational Medicine，Cell Metabolism等杂志发表论文70多篇，引用超1万次。
代表性论文：
1.Chunxia Zhang#, Yusheng Chen#, Baofa Sun#, Lu Wang#, Ying Yang#, Dongyuan Ma, Junhua Lv, Jian Heng, Yanyan Ding, Yuanyuan Xue, Xinyan Lu, Wen Xiao, Yun-Gui Yang*, Feng Liu*. m6A modulates haematopoietic stem and progenitor cell specification. Nature 549(7671): 273-276 (2017)（入选2017年中国生命科学研究领域十大进展）.
2.Yihao Liu#, Jiayu Lin#, Zhengwei Yu#, Xueying Li#, Xueqi Lv#, Pengyi Liu#, Xiuqiao Sun, Zhen Zhang, Xia Gao, Keyan Sun, Dan Li, Jingfeng Li, Yang Liu, Yu Jiang, Siyi Zou, Jianping Lin, Baofa Sun*, Da Fu*, Baiyong Shen*. Tumor-associated Schwann cell remodeling under metabolic stress via lactate sensing orchestrates pancreatic ductal adenocarcinoma development. Cell Metabolism. S1550-4131(25)00335-3 (2025).
3.Sai Xiao#, Shoubao Ma#, Baofa Sun#, Wenchen Pu, Songqi Duan, Jingjing Han, Yaqun Hong, Jianying Zhang, Yong Peng, Chuan He, Ping Yi*, Michael A. Caligiuri*, Jianhua Yu*. The tumor-intrinsic role of the m6A reader YTHDF2 in regulating immune evasion. Science Immunology 9(95): eadl2171 (2024).
4.Shoubao Ma#, Baofa Sun#, Songqi Duan#, Jingjing Han#, Tasha Barr, Jianying Zhang, Marc B. Bissonnette, Marcin Kortylewski, Chuan He, Jianjun Chen，Michael A. Caligiuri*, Jianhua Yu*. YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8(+) T cells. Nature Immunology 24(2): 255-266 (2023).
5.Yihao Liu#, Minmin Shi#, Xingfeng He#, Yizhi Cao, Pengyi Liu, Fanlu Li, Siyi Zou, Chenlei Wen, Qian Zhan, Zhiwei Xu, Jiancheng Wang*, Baofa Sun*, Baiyong Shen*. LncRNA-PACERR induces pro-tumour macrophages via interacting with miR-671-3p and m6A-reader IGF2BP2 in pancreatic ductal adenocarcinoma. Journal of Hematology & Oncology 15(1):52 (2022).
6.Yaqian Li#, Qingyang Zhang#, Baofa Sun#, Yidi Ma, Ye Zhang, Min Wang, Congcong Ma, Honghui Shi, Zhijing Sun, Juan Chen, Yun-Gui Yang*, Lan Zhu*. Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse, Nature Communications 12(1): 87 (2021).
7.Xin Chen#, Ang Li#, Bao-Fa Sun#, Ying Yang#, Ya-Nan Han#, Xun Yuan#, Ri-Xin Chen, Wen-Su Wei, Yanchao Liu, Chun-Chun Gao, Yu-Sheng Chen, Mengmeng Zhang, Xiao-Dan Ma, Zhuo-Wei Liu, Jun-Hang Luo, Cong Lyu, Hai-Lin Wang, Jinbiao Ma, Yong-Liang Zhao, Fang-Jian Zhou, Ying Huang*, Dan Xie*, Yun-Gui Yang*. 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs. Nature Cell Biology 21(8): 978–990 (2019).
8.Jun-Ya Peng#, Bao-Fa Sun#, Chuan-Yuan Chen#, Jia-Yi Zhou#, Yu-Sheng Chen#, Hao Chen, Lulu Liu, Dan Huang, Jialin Jiang, Guan-Shen Cui, Ying Yang, Wenze Wang, Dan Guo, Menghua Dai, Junchao Guo, Taiping Zhang, Quan Liao, Yi Liu, Yong-Liang Zhao, Da-Li Han#, Yupei Zhao*, Yun-Gui Yang*, Wenming Wu*. Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma. Cell Research 29(9): 725-738 (2019).
9.Shiming Peng#, Wen Xiao#, Dapeng Ju#, Baofa Sun#, Nannan Hou, Qianlan Liu, Yanli Wang, Haijiao Zhao, Chunchun Gao, Song Zhang, Ran Cao, Pengfei Li, Huanwei Huang, Yongfen Ma, Yankai Wang, Weiyi Lai, Zhixiong Ma, Wei Zhang, Song Huang, Hailin Wang, Zhiyuan Zhang, Liping Zhao, Tao Cai, Yong-Liang Zhao, Fengchao Wang, Yongzhan Nie, Gang Zhi, Yun-Gui Yang*, Eric Erquan Zhang*, Niu Huang*. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Science Translational Medicine 11(488): eaau7116 (2019).
10.Rong Wu#, Ang Li#, Baofa Sun#, Jian Guang Sun#, Jinhua Zhang#, TingZhang#, Yusheng Chen, Yujie Xiao, Yuhao Gao, Qingyang Zhang, Jun Ma, Xin Yang, Yajin Liao, Wei-Yi Lai, Xiaolong Qi, Shukun Wang, Yousheng Shu, Hai-Lin Wang, Fengchao Wang*, Yun-Gui Yang*, Zengqiang Yuan*. A novel m6A reader Prrc2a controls oligodendroglial specification and myelination. Cell Research 29(1): 23-41 (2019).
社会兼职：
中国生物信息学表观遗传信息学专业委员会委员
荣誉称号：
2016年获得中科院青年创新会会员称号
2024年获得天津市青年科技人才
2024年获得北京市自然科学奖二等奖
2023-2024年获得科睿唯安2023-2024年度“全球高被引科学家”