姓名：陈悦
职称：教授
邮箱：yuechen@nankai.edu.cn
办公电话：022-85358387
办公地址：津南校区综合实验楼C524
研究方向：靶向癌症干细胞的天然产物的合成；靶向癌症干细胞的药物化学；复杂抗癌天然产物靶点探索；
教育背景与工作经历：
1990年9月-1994年7月，湖南师范大学，学士学位；
1994年9月-1997年6月，中国科学院上海有机所，硕士学位；
1997年9月-2003年5月，University of Notre Dame，博士学位；
2003年8月-2007年12月 美国Kosan Biosciences，Scientist I/II；
2008年01月-2020年10月 南开大学药学院 教授 博士生导师；
2020年10月-至今 南开大学化学学院 教授 博士生导师。
研究成果：
研究方向：靶向癌症干细胞天然产物的药物化学与靶点探索：
（1）脂肽类和聚酮类天然产物：Rakicidins、BE43547A2、Vinylamycin、Microtermolides、Boholamide A、Neaumycin B类似物、Cyclotheonellazole、Majusculamide D等，确定部分化合物对癌症干细胞的选择性与作用靶点。
（2）萜类天然产物：Parthenolide、Ovatodiolide、Alterbrassicicene、5S-Heudelotinone、Fusicoccane、Hypocretenolides。两个候选药物进入临床试验，其中的ACT001进入临床三期，并获得中国药监局授予的突破性治疗品种、美国FDA授予的快速通道等资质，是罕见的针对NF-KB/STAT3双靶点开展大规模三期临床试验的候选新药。
代表性论文：
1. Can Liu, Can Liu, Guang-ju Liu, Meng-meng Wang, Yan Jiao, Yuan-jun Sun, Hui Guo, Liang Wang, Ya-xin Lu, Yue Chen*,Ya-hui Ding*, BE-43547A2 exerts hypoxia-selective inhibition on human pancreatic cancer cells through targeting eEF1A1 and disrupting its association with FoxO1,Acta Pharmacol Sin,. 2025 May;46(5):1433-1444.
2. Qing Meng, Jianshuang Guo, Ke Lv, Yang Liu, Jin Zhang, Mingyue Li, Xirui Cheng, Shenghua Chen, Xiaoguang Huo, Quan Zhang*, Yue Chen*, Jing Li*, 5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiotadependent manner, Acta Pharmaceutica Sinica B, 2024 May,14(5):2153-2176
3. Sen Zhang, Songming Zhang, Yunlong Fan, Xuhai Zhang, Jing Chen, Chaofan Jin, Sisi Chen, Liang Wang,* Quan Zhang,* and Yue Chen*, Total Synthesis of the Proposed Structure of Neaumycin B, Angew Chem Int Ed. 2023, Dec 18; 62(51):e202313186.
4.Can Liu, Liang Wang,* Yuanjun Sun, Xiuhe Zhao, Tianyang Chen, Xiuwen Su, Hui Guo, Qin Wang, Xiaonan Xi, Yahui Ding,* Yue Chen.*, Probe Synthesis Reveals Eukaryotic Translation Elongation Factor 1 Alpha 1 as the Anti-Pancreatic Cancer Target of BE-43547A2. Angew. Chem. Int. Ed. 2022, Aug 22; 61(34):e20220695361.
5.Bolin Chen, Qianwei Wu, Dongdong Xu, Xijing Zhang, Yahui Ding, Shiqi Bao, Xuemei Zhang, Liang Wang*, Yue Chen*,A Two-phase Approach to Fusicoccane Synthesis To Uncover a Compound That Reduces Tumourigenesis in Pancreatic Cancer Cells, Angew. Chem. Int. Ed. 2022 May 2; 61(19):e202117476
6. Yingjun Cui, Mengyi Zhang, Honglei Xu, Tingrong Zhang, Songming Zhang, Xiuhe Zhao, Peng Jiang, Jing Li,* Baijun Ye, Yuanjun Sun, Mukuo Wang, Yangping Deng, Qing Meng, Yang Liu, Qiang Fu, Liang Wang,* Yue Chen.*, Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo 2 Biological Evaluation for Acute Lung Injury. J. Med. Chem. 2022, Feb 24; 65(4):2971-2987
7. Yahui Ding, Qingqing Xue, Shuo Liu, Kai Hu, Da Wang, Tianpeng Wang, Ye Li, Hongyu Guo, Xin Hao, Weizhi Ge, Yan Zhang, Ang Li, Jing Li, * Yue Chen, * Quan Zhang*., Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme In Vivo. J. Med. Chem.2020, Feb 27;63(4):1597-1611.
8. Junhong Xiang, Yahui Ding,* Jiaxin Li, Xiuhe Zhao, Yuanjun Sun, Da Wang, Liang Wang,* Yue Chen*, Ovatodiolides: Scalable Protection-free Syntheses, Configuration Determination and Biological Evaluation against Hepatic Cancer Stem Cells. Angew. Chem. Int. Ed. 2019, Jul 29;58(31): 10587-10590.
9. Jing Li, Shanshan Li, Jianshuang Guo, Qiuying Li, Jing Long, Cheng Ma, Yahui Ding, Chunli Yan, Liangwei Li, Zhigang Wu, He Zhu, Keqin Li, Liuqing Wen, Quan Zhang, Qingqing Xue, Caili Zhao, Ning Liu, Ivaylo Ivanov, Ming Luo, Rimo Xi, Haibo Long, Peng Wang, *Yue Chen,*Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia. J. Med. Chem., 2018,May 10;61(9): 4155-4164.(ACS editor’s choice)
10.Yuanjun Sun, Yahui Ding1,Dongmei Li, Ruifei Zhou, Xiuwen Su, Juan Yang, Xiaoqian Guo, Chuanke Chong, Jinghan Wang, Weicheng Zhang, Cuigai Bai, Liang Wang*, Yue Chen,* Cyclic Depsipeptide BE-43547A2: Synthesis and Activity against Pancreatic Cancer Stem Cells. Angew. Chem. Int. Ed.,2017, Nov 13;56(46): 14627-14631. (Hot Paper, Press Release)
11.Jinghan Wang, Beijia Kuang, Xiaoqian Guo, Jianwei Liu, Yahui Ding, Jiangnan Li, Shende Jiang, Ying Liu, Fang Bai, Luyuan Li, Quan Zhang, Xiao-Yu Zhu, Bo Xia, Chun-Qi Li, Liang Wang*, Guang Yang*, Yue Chen,* Total Syntheses and Biological Activities of Vinylamycin Analogs. J. Med. Chem., 2017,Feb 9;60(3): 1189-1209.
12. Feng Sang,# Yahui Ding,# Jinghan Wang,# Bingxia Sun,# Jianlei Sun,# Yan Geng,# Zhang Zhang, Ke Ding, Ling-Ling Wu, Jian-Wei Liu, Cuigai Bai, Guang Yang,* Quan Zhang,* Lu-Yuan Li,* Yue Chen,* Structure−Activity Relationship Study of Rakicidins: Overcoming Chronic Myeloid Leukemia Resistance to Imatinib with 4 Methylester-Rakicidin A. J. Med. Chem., 2016, Feb 11;59(3):1184-1196.
13.Zhong-Jin Yang, Wei-Zhi Ge, Qiu-Ying Li, Yaxin Lu, Jian-Miao Gon, Bei-Jia Kuang, Xiaonan Xi, Haiting Wu, Quan Zhang,* Yue Chen,* Syntheses and Biological Evaluation of Costunolide, Parthenolide and Their Fluorinated Analogues. J. Med. Chem.2015, Sep 10;58(17):7007-7020.
14.Feng Sang, Dongmei Li, Xiaolong Sun, Xianqiang Cao, Liang Wang, Jianlei Sun, Bingxia Sun, Lingling Wu, Guang Yang, Xiaoqian Chu, Jinghan Wang, Changming Dong, Yan Geng, Hong Jiang, Haibo Long, Sijia Chen, Guiyan Wang, Shuzhong Zhang, Quan Zhang, Yue Chen,* Total Synthesis and Determination of the Absolute Configuration of Rakicidin A. J. Am. Chem. Soc., 2014, Nov 5;136(44), 15787-15791.
15.Jing Long, Shan-Feng Zhang, Pan-Pan Wang, Xue-Mei Zhang, Zhong-Jin Yang, Quan Zhang*, Yue Chen,*Total syntheses of parthenolide and its analogs with macrocyclic stereocontrol. J. Med. Chem., 2014,Aug 28;57(16):7098-7112.
社会兼职：
中国药学药物化学学会委员
荣誉称号：
2013年，国家千人计划(创业)；
2013年，教育部新世纪优秀人才；
2016年，国家自然科学基金杰出青年科学基金获得者
2013年，天津市千人计划
2017年，天津市“131”创新型人才培养工程第一层次
2018年，天津市创新人才推进计划重点领域创新团队，负责人
2021年，天津市杰出人才；
2017年，南开大学“百名青年学术带头人”；
2021年，天津市科学技术奖技术发明一等奖，第一人